“…5â8 To date, a large number of spectroscopic methods (e.g., colorimetric, fluorometric, and surface-enhanced Raman scattering (SERS)) and electrochemical approaches have been reported for detection of ALP activity. 9â14 Due to their operational simplicity and high spatial temporal sensitivity, fluorometric methods using organic dyes, 15,16 fluorescent polymers, 9,17 inorganic quantum dots (QDs), or noble metal nanoclusters 18â20 as indicators for ALP detection have been extensively explored.…”