Ultrasensitive electrochemical biosensor based on graphite oxide, Prussian blue, and PTC-NH2 for the detection of α2,6-sialylated glycans in human serum

Gao, Liuliu; He, Junlin; Xu, Wailan; Zhang, Jing; Hui, Junmin; Guo, Yanlei; Li, Wenjuan; Yu, Chao

doi:10.1016/j.bios.2014.06.031

Cited by 36 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,16 In previous studies, they have been demonstrated to be applicable to the sensing of hydrogen peroxide at a low applied potential, allowing the integration of oxidase enzymes while reducing other electrochemical interferents. 3,15,25,[29][30][31][32][33][34][35][36][37][38] Other Prussian blue-based biosensors, such as glucose, 25,[39][40][41][42][43][44][45][46][47][48][49][50][51] pH, 22 lactate, 38,[52][53][54] antigen, 55 cholesterol, 56,57 DNA, 24,54,58 glycan, 59 antihypertensive drug, 23 carcinoma antigen, 60 ion, 24,61 uric acid, 62 ascorbic acid, 63 and nicotinamide adenine dinucleotide (NADH) [64]…”

Section: Introductionmentioning

confidence: 99%

New faces of porous Prussian blue: interfacial assembly of integrated hetero-structures for sensing applications

et al. 2015

View full text Add to dashboard Cite

Prussian blue (PB), the oldest synthetic coordination compound, is a classic and fascinating transition metal coordination material. Prussian blue is based on a three-dimensional (3-D) cubic polymeric porous network consisting of alternating ferric and ferrous ions, which provides facile assembly as well as precise interaction with active sites at functional interfaces. A fundamental understanding of the assembly mechanism of PB hetero-interfaces is essential to enable the full potential applications of PB crystals, including chemical sensing, catalysis, gas storage, drug delivery and electronic displays. Developing controlled assembly methods towards functionally integrated hetero-interfaces with adjustable sizes and morphology of PB crystals is necessary. A key point in the functional interface and device integration of PB nanocrystals is the fabrication of hetero-interfaces in a well-defined and oriented fashion on given substrates. This review will bring together these key aspects of the hetero-interfaces of PB nanocrystals, ranging from structure and properties, interfacial assembly strategies, to integrated hetero-structures for diverse sensing.

show abstract

Section: Introductionmentioning

confidence: 99%

New faces of porous Prussian blue: interfacial assembly of integrated hetero-structures for sensing applications

et al. 2015

View full text Add to dashboard Cite

show abstract

“…AuNPs immobilized with graphite oxide (GO), Prussian blue (PB), and PTC-NH 2 (an ammonolysis product of 3,4,9,10-perylenetetracarboxylic dianhydride) nanocomposite GO-PB-PTC-NH 2 modified glassy carbon electrode (GCE) linked to SNAs could detect α2,6-sialylated glycans in serum [108]. Lectin-tagged fluorescent polymeric NPs (35 nm) could detect cellular sialic acid expression [109].…”

Section: Nanotechnology Bioimaging Application Detection Of Cellularmentioning

confidence: 99%

Nanotechnology and sialic acid biology

Ghosh¹

2020

Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease

View full text Add to dashboard Cite

“…There are also increasing reports on the development of ultrasensitive biosensors for detecting specific sialylated glycans for cancer diagnosis. These include gold nanoparticle bound Sambucus nigra agglutinin based sensors that bind specifically to α‐2,6‐sialylated glycans with detection limits of 0.03 pg/mL, Prussian blue‐based nanocomposite sensors, and boronic acid‐functionalized peptide‐based fluorescent sensors with a high specificity for sLe x cell‐surface glycans . In a different glycoproteomic approach, CMP[ 14 C]Neu5Ac and ST3Gal II were used in an “exchange sialylation” process to radiolabel and characterize cancer‐associated mucin type O ‐glycans, which resulted in the identification of a unique 25‐ to 35‐kDa sialylated glycoprotein in pancreatic tumors …”

Section: Biological Tools Toward Imagingmentioning

confidence: 99%

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities

Szabo

Skropeta

2016

Medicinal Research Reviews

View full text Add to dashboard Cite

Hypersialylation of tumor cell surface proteins along with a marked upregulation of sialyltransferase (ST) activity is a well-established hallmark of cancer. Due to the critical role of STs in tumor growth and progression, ST inhibition has emerged as a potential new antimetastatic strategy for a range of cancers including pancreatic and ovarian. Human STs are divided into subtypes based on their linkage and acceptor molecule, with each subtype controlling the synthesis of specific sialylated structures with unique biological roles. This has important implications for inhibitor development, as STs also play significant roles in immune responses, inflammation, viral infection, and neurological disorders. Thus, the current goal in order to advance to the clinic is the development of subtype selective, cell-permeable and synthetically accessible, smallmolecule ST inhibitors. Herein is a comprehensive review of the latest developments in ST inhibitors from design, Nature, and high-throughput screening, addressing both the challenges and opportunities in targeting cell surface sialylation. The review features an overview of the biological evaluation methods, computational and imaging tools, inhibitor molecular diversity, and selectivity toward ST subtypes, along with the emerging role of ST inhibitors as diagnostic tools for disease imaging.

show abstract

Ultrasensitive electrochemical biosensor based on graphite oxide, Prussian blue, and PTC-NH2 for the detection of α2,6-sialylated glycans in human serum

Cited by 36 publications

References 35 publications

New faces of porous Prussian blue: interfacial assembly of integrated hetero-structures for sensing applications

New faces of porous Prussian blue: interfacial assembly of integrated hetero-structures for sensing applications

Nanotechnology and sialic acid biology

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities

Contact Info

Product

Resources

About