Ultrasmall Biocompatible Bi₂Se₃ Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer

Abstract

Sub-3 nm ultrasmall BiSe nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (η = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive Tc for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall BiSe nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free 64Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

“…27,28 On the other hand, integration of multiple imaging and therapy functions within such ultrasmall nanoscale structures often would require relatively complicated design and fabrication processes. 29,30 Hence, it would be of great interests to develop simple methods for the fabrication of multifunctional nanoparticles with ultrasmall hydrodynamic sizes in physiological conditions such as the plasma environment, so as to enable rapid renal clearance of those nanoparticles from the body, after their missions in cancer imaging and enhanced therapy are accomplished.…”

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

“…Compared to other conventional therapeutic techniques, PTT boasts many merits such as the simplicity, minimal invasiveness, low incidence of complications, as well as the high spatial and temporal precision of NIR light 8, 9, 10, 11. Various types of nanoagents have been explored to attain better PTT performance12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 and in the treatment, intravenous injection of the nanoagents (to mice, for example) is followed by high‐power NIR laser irradiation for ablation 25, 26, 27, 28, 29. Despite recent progress, clinical adoption of PTT still faces several hurdles.…”

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

“…Therefore, several Bi-based nanomaterials, such as Bi 2 S 3 nanodots, 32 Bi 2 S 3 nanorods 33 and Bi 2 Se 3 NPs with different morphologies, [34][35][36][37][38] have been proposed as X-ray CT contrast agents and radio-/photothermal therapy sensitizing agents. Compared with orthorhombic Bi 2 S 3 , the topological insulator Bi 2 Se 3 has a two-dimensional layered rhombohedral structure with a unique surface electronic state 39,40 and has aroused increasing interest in biomedical applications due to its multifunctionality and good biocompatibility.…”