Ultrasmall black phosphorus quantum dots: synthesis, characterization, and application in cancer treatment

Wang, Mingqian; Liang, Ying; Liu, Yajun; Ren, Guohong; Zhang, Zhicheng; Wu, Shishan; Shen, Jian

doi:10.1039/c8an01612g

Cited by 51 publications

(27 citation statements)

References 47 publications

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“…Nanoparticles are particles with the size range of 1-100 nm, which have drawn attractive scientific attention due to their versatile potential applications in optical, electronic, and biomedical fields. [60][61][62][63][64][65][66][67][68][69] Qian et al [29] reported that Se nanoparticles with an average diameter of ≈3 nm and a narrow size distribution, were successfully fabricated in large quantities by liquid-phase exfoliation using NbSe 2 powders as the source material and N-methyl-2-pyrrolidone (NMP) as the dispersant (Figure 2a). High-resolution transmission electron microscopy (HRTEM) image (Figure 2a, inset) reveals that the as-prepared Se nanoparticles have the characteristic of crystalline lattice planes and the d-spacing is 0.23 nm.…”

Section: D Se Nanoparticlesmentioning

confidence: 99%

“…The fundamental light-matter interaction in nanomaterials can also be probed and understood by Raman spectroscopy. [22,63,157,161,162] Figure 11a shows the typical Raman spectrum of a 15 nm thick Se nanosheet at an angle θ of 45°, where θ is defined as an angle between laser polarization direction and [0001] helical chain direction of a Se nanosheet. Three active Raman photon modes are clearly observed, in good accordance with the previous observations in bulk Se.…”

Section: Raman Spectroscopymentioning

confidence: 99%

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Recent Advances in Semiconducting Monoelemental Selenium Nanostructures for Device Applications

Huang

Wang

et al. 2020

Adv Funct Materials

136

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Investigations into semiconductor nanomaterials from both an academic and industrial point of view are of great significance. Selenium (Se) nanostructures, as narrow bandgap semiconductors, have a variety of potential applications in the fabrication of many high-performance devices. The past decades have witnessed rapid development in new strategies for synthesizing Se nanostructures with controlled sizes, shapes, and structures, whose diverse structure-dependent nature enables functional Se nanomaterials to have great potentials for modern applications. This review focuses on the synthesis and morphology control of intriguing Se nanostructures, the latest progress in understanding the fundamental properties of Se nanostructures, and the recent advances in high-performance Se nanomaterial-based devices for diverse applications. Finally, the challenges and future opportunities for Se nanostructures and Se-related devices are also discussed.

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Section: D Se Nanoparticlesmentioning

confidence: 99%

Section: Raman Spectroscopymentioning

confidence: 99%

Recent Advances in Semiconducting Monoelemental Selenium Nanostructures for Device Applications

Huang

Wang

et al. 2020

Adv Funct Materials

136

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“…Though mechanical exfoliation and liquid phase ultrasonic exfoliation have been recognized as the two popular ones for the nano‐BP preparation, some other methods are still applicable, such as electrochemical exfoliation, solvothermal treatment and so on. In the electrochemical exfoliation, bulk BP and Na 2 SO 4 were used as working electrode and the ionic solution, respectively .…”

Section: Nano‐bp Synthesismentioning

confidence: 99%

“…As displayed in Figure a, bulk BP was subjected to grind treatment and subsequently solvothermal treatment with saturated NaOH‐NMP solution as solvent, achieving BPQDs with ultrasmall size of about 2.1 ± 0.9 nm and good dispersion (Figure b–e). Furthermore, BPQDs exhibited blue‐green fluorescence under the irradiation of UV light of 365 nm, providing great potential for developing novel bioimaging platform and fluorescent sensing technique . In addition, the milling crushing of bulk BP was reported to attain few layered thin BP nanoparticles with the yield of over 60 wt% .…”

Section: Nano‐bp Synthesismentioning

confidence: 99%

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Xia

Guo

2019

Adv Funct Materials

200

115

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Black phosphorus nanostructures (nano-BPs) include BP nanosheets, BP quantum dots, and BP nanoparticles. Since first being discovered in 2014, nano-BP has become one of the most popular nanomaterials. Nano-BP has many unique properties, such as excellent surface activity, tunable bandgap, high carrier mobility, moderate on/off ratio, excellent biocompatibility, good biodegradation, etc., all of which make nano-BP particularly attractive in biomedicine and biosensing. This review article comprehensively summarizes recent advances in synthesis, functionalization, biomedicine, and biosensing applications of nano-BP. Different methods are first introduced, such as mechanical cleavage, liquid-phase ultrasonic exfoliation, electrochemical exfoliation, solvothermal treatment, and acoustic-microfluidic stripping, for making the nano-BP. Then two strategies are emphasized to enhance ambient stability of nano-BP, namely physical encapsulation and chemical modification. Next, how to develop nano-BP as advanced imaging agents, nanocarriers, and nanomedicine for bioimaging (fluorescence imaging, thermal imaging, and photoacoustic imaging) and disease treatment (phototherapy and photo/chemical/immune synergistic therapy) is demonstrated. The biosensing applications on nano-BP is introduced, including electrochemical biosensor, fluorescence biosensor, chemiluminescence biosensor, electrogenerated chemiluminescence biosensor, and colorimetric biosensor. Finally, the current challenges and future perspectives on nano-BP in bioapplications are discussed. Nano-BP SynthesisLayered nanomaterials are usually exfoliated from bulk crystals. [35] Compared with bulk materials, monolayer or fewlayer nanomaterials possess the enhanced surface area, excellent physiochemical activity and optoelectronic property. The exfoliation from bulk crystal to monolayer or few-layer nanosheets has been widely applied for preparing almost all the 2D nanomaterials, graphene, MoS 2 , MXene nanosheets, etc. [36] Bulk BP, similar to graphite, is the stacking of layered BP nanosheets via the weak van der Waals force. The destruction of the external driving forces to the weak van der Waals interaction between the stack layers greatly contributes to the exfoliation of nano-BP from the bulk counterparts. Mechanical exfoliation and liquid phase ultrasonic exfoliation are the two most popular approaches, and some other methods were also involved, electrochemical exfoliation and solvothermal treatment, for instance. Table 1 summarizes the advantages and limitations of different exfoliation methods. Mechanical ExfoliationMechanical exfoliation, also called scotch-tape delamination, mainly utilizes the larger binding energy between the substrate and layered materials than van der Waals forces in Figure 2. a) Schematic illustration of meta-assisted mechanical exfoliation for FLBP. b) The left is FLBPs exfoliated using the normal scotch-tape microcleavage, and the right is FLBP exfoliated using Au-assisted method, and c) the total area of FLBP on 10 different samples. ...

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“…Because of the unique photophysical properties like brightness, photo‐stability, narrow emission, and broad absorption, quantum dots (QDs) have been extensively exploited for cell tracking, bio‐sensing and imaging in vivo . Nevertheless, such growing applications increased concerns over environmental exposure because of the potential toxicity of QDs.…”

Section: Introductionmentioning

confidence: 99%

Involvement of ABC transporters in the efflux and toxicity of MPA‐COOH‐CdTe quantum dots in human breast cancer SK‐BR‐3 cells

Huang

Wang

Zhang

2019

J Biochem & Molecular Tox

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This paper aimed to study the possible involvement of adenosine triphosphate‐binding cassette (ABC) transporters in the detoxification of quantum dots (QDs) in human breast carcinoma (SK‐BR‐3) cells. The effects of QD sizes on such interactions were also evaluated. For this purpose, we used monodispersed MPA‐COOH‐CdTe QDs with different diameters (emission length at 560 and 625 nm, named as QD‐560 and QD‐625). Such QDs tended to accumulate in cells and cause significant toxicity. Using specific inhibitors of ABC transporters, the cellular accumulation and toxicity of QDs in SK‐BR‐3 cells were significantly affected. Moreover, treatment of QDs caused concentration‐ and time‐dependent induction of ABC transporters. Furthermore, the induction effects of smaller QDs were found to be greater than larger ones at equivalent concentrations, suggesting a size‐dependent recognition of substrates by ABC transporters. Overall, these results provided important support for the modulation of QDs toxicity by ABC transporters.

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Ultrasmall black phosphorus quantum dots: synthesis, characterization, and application in cancer treatment

Abstract: We synthesized black phosphorus quantum dots with good fluorescence performance and excellent biocompatibility, and highlighted their great potential in the photothermal therapy of cancer.

Cited by 51 publications

References 47 publications

Recent Advances in Semiconducting Monoelemental Selenium Nanostructures for Device Applications

Recent Advances in Semiconducting Monoelemental Selenium Nanostructures for Device Applications

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Involvement of ABC transporters in the efflux and toxicity of MPA‐COOH‐CdTe quantum dots in human breast cancer SK‐BR‐3 cells

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