Ultrasonic Absorption by Liposomes

Maynard, Valerie M.; Magin, Richard L.; Strom‐Jensen, Philip R.; Dunn, F.

doi:10.1109/ultsym.1983.198171

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…The ultrasound absorption temperature characteristics for these lipids and structures (at atmospheric pressure) have been reported at 3 MHz. 24 Figure 2 shows that the (aA)Aim findings correlate well. 23 The B/ A increase with temperature of the two different structures reaches maximum values at the respective atmospheric Tm• as confirmed by ultrasound absorption and differential scanning calorimetric studies (DSC) 25…”

Section: Thermodynamic Methods B/a Analysis Of Liposomes Via Single Rementioning

confidence: 77%

Thermodynamic method of B/A analysis of liposome suspensions: prediction via single relaxation theory

Tata

Dunn²

1992

Journal of Ultrasound in Medicine

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Section: Thermodynamic Methods B/a Analysis Of Liposomes Via Single Rementioning

confidence: 77%

Thermodynamic method of B/A analysis of liposome suspensions: prediction via single relaxation theory

Tata

Dunn²

1992

Journal of Ultrasound in Medicine

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“…Although this rise in temperature is still below the transition temperature of the DPPC (41.3 °C), this does not eliminate a possible thermal effect capable of enhancing the release which is mainly driven by the mechanical effect of the LFUS. Previous studies have shown that ultrasonic absorbance by the lipid bilayer occurs during lipid phase transition, while the absorbance by the membrane is diminishing below the phase transition bilayer [75][76] . This suggests that liposomal drug release, achieved when working below the phase transition temperature is attributed to mechanical and possible thermal effects due to the rise in temperature rather than absorbance of ultrasound by the lipids.…”

Section: Discussionmentioning

confidence: 98%

Effect of Pegylation and Targeting Moieties on the Ultrasound-Mediated Drug Release from Liposomes

Awad

Paul

Mahmoud

et al. 2019

ACS Biomater. Sci. Eng.

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The use of targeted liposomes encapsulating chemotherapy drugs enhances the specific targeting of cancer cells, thus, reducing the side effects of these agents and providing a more patient-friendly treatment.Targeted pegylated (stealth) liposomes have the ability to safely deliver their loaded drugs to the cancer cells by targeting specific receptors overly expressed on the surface of these cells. Applying ultrasound as an external stimulus will safely trigger drug release from these liposomes in a controlled manner. In this study, we investigated the release kinetics of the model drug "calcein" from targeted liposomes sonicated with low-frequency ultrasound (20-kHz). Our results showed that pegylated liposomes were more sonosensitive compared to non-pegylated liposomes. A comparison of the effect of three targeting moieties conjugated to the surface of pegylated liposomes, namely human serum albumin (HSA), transferrin (Tf) and arginylglycylaspartic acid (RGD), on calcein release kinetics was conducted. The fluorescence results showed that HSA-PEG and Tf-PEG liposomes were more sonosensitive (showing higher calcein release following the exposure to pulsed LFUS) compared to the control pegylated liposomes. Thus, adding more acoustic benefits to their targeting efficacy.

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“…Briefly, they subjected liposomes comprised of DMPC or DPPC to 1.42 and 2.11 MHz US, respectively, and recorded the ultrasonic absorption and velocity of the samples. Enhanced ultrasonic absorbance only occurred at the phase Tm; below the phase transition, it was observed that US was hardly absorbed by the membrane [98,99]. These findings suggest that, when working at temperatures below the phase transition of the liposome, the mechanism of release is independent of the liposome’s absorbance of US but is dependent on the local cavitation and RTFs as well as heating of the surrounding tissue.…”

Section: Ultrasoundmentioning

confidence: 99%

Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy

et al. 2019

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This review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from liposomes in a tumor in a spatially-specific manner. Each section explores the mechanism(s) of drug release that can be achieved using liposomes in conjunction with the external trigger. Subsequently, the treatment’s formulation factors are discussed, highlighting the parameters of both the therapy and the medical device. Additionally, the pre-clinical and clinical trials of each triggered release method are explored. Lastly, the advantages and disadvantages, as well as the feasibility and future outlook of each triggered release method, are discussed.

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Ultrasonic Absorption by Liposomes

Cited by 4 publications

References 4 publications

Thermodynamic method of B/A analysis of liposome suspensions: prediction via single relaxation theory

Thermodynamic method of B/A analysis of liposome suspensions: prediction via single relaxation theory

Effect of Pegylation and Targeting Moieties on the Ultrasound-Mediated Drug Release from Liposomes

Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy

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