Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment

Husseini, Ghaleb A.; Pitt, William G.

doi:10.1002/jps.21444

Cited by 77 publications

(75 citation statements)

References 132 publications

(159 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results from this study indicated that the permeability coefficient of glycerol not only in normal breast tissues, but also in breast cancer tissues after treatment with ultrasound is larger than that in tissues without ultrasound, moreover, there was a significant difference in relative permeability coefficient of glycerol between breast cancer tissues and normal breast tissues (p< 0.05). This phenomenon is consistent with the previous findings that ultrasound caused the increase of cell membrane permeability in TDD [77][78][79][80].…”

Section: Resultssupporting

confidence: 94%

Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

et al. 2010

View full text Add to dashboard Cite

Here we examined the effect of human normal breast (NB) and breast cancer (BC) tissues in vitro after treatment with glycerol in conjunction with ultrasound (surgeonperformed, SP) by OCT for functional imaging to monitor. 60% glycerol (G) and SP was simultaneously applied for 5 min. Depth-and time-resolved profiles for OCT signal enhancement were presented. The results show that OCT imaging depth of breast tissues after treatment with 60% G in combined with SP more obviously improved than that after application of glycerol alone. The permeability coefficient of 60% glycerol in 60% G/NB, 60% G/BC, 60% G/SP/NB, and 60% G/SP/BC were (0.91±0.02)×10 cm/s, (1.63±0.04)×10−5 cm/s, and (7.98±0.19)×10 −5 cm/s, respectively. The permeability coefficient of glycerol in 60% G/SP/NB was 1.84-fold than that in 60% G/NB, but there was 2.54-fold on permeability coefficient comparing 60% G/SP/BC with that in 60% G/BC. The results from this study indicated that the permeability coefficient of glycerol not only in normal breast tissues, but also in breast cancer tissues after treatment with ultrasound is larger than that in tissues without ultrasound. The relative permeability coefficient of 60% glycerol diffusion of normal breast and breast cancer treatment with ultrasound than without ultrasound for 5 min

show abstract

Section: Resultssupporting

confidence: 94%

Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

et al. 2010

View full text Add to dashboard Cite

show abstract

“…This phenomenon is consistent with previous findings that ultrasound caused the increase of cell membrane permeability in TDD. [47][48][49][50] The quantitative reductions of attenuation coefficients at 60 min according to Eq. ͑3͒ for skin samples under different treatment procedures ͑40% G, 60% G, 80% G, 40% G/SP, 60% G/SP, and 80% G/SP͒ are shown in Figs.…”

Section: With Ultrasoundmentioning

confidence: 99%

In vitro study of ultrasound and different-concentration glycerol–induced changes in human skin optical attenuation assessed with optical coherence tomography

et al. 2010

View full text Add to dashboard Cite

Abstract. Previous studies have demonstrated the ultrasound-induced skin optical clearing enhancement with topical application of 60% glycerol ͑G͒ on in vitro porcine skin and in vivo human skin. Our purpose was to find the relation between the effect of optical skin clearing and different concentrations of glycerol and to find more effective ultrasound-glycerol combinations on optical skin clearing. The enhancement effect of ultrasound ͓Sonophoresis ͑SP͒ delivery͔ in combination with 40% G, 60% G, and 80% G on in vitro human skin optical clearing was investigated. Light imaging depths of skin were measured using optical coherence tomography. Different concentrations of glycerol and ultrasound with a frequency of 1 MHz and an intensity of 0.5 W / cm 2 was simultaneously applied for 15 min. The results show that with the increase of concentration of glycerol, the optical clearing of skin is much improved. Optical clearing capability of glycerol was more enhanced with simultaneous application of ultrasound compared with glycerol alone. The attenuation coefficients of skin tissues after application of 40% G/SP, 60% G/SP, and 80% G/SP decreased approximately 11.8%, 18.5%, and 20.0% at 15 min compared with 40% G, 60% G, and 80% G alone, respectively. The greatest decrease in attenuation coefficients at 60 min was approximately 52.3% and 63.4% for 80% G ͑without ultrasound͒ and 80% G/SP ͑with ultrasound͒, respectively, which are 2.1-fold and 2.6-fold to that in the 40% G.

show abstract

“…The delivery of doxorubicin to cancer cells and tumors using drug loaded polymeric micelles combined with ultrasound has been pioneered by Rapaport, Pitt and coworkers and several excellent reviews are available [17,22]. The micelles used in these studies have focused almost entirely on the triblock copolymers of poly(ethylene oxide) and poly(propylene oxide) known as poloxamer or Pluronic ™ polymers [7,10,17,19,23].…”

Section: Introductionmentioning

confidence: 98%

Increased accumulation of paclitaxel and doxorubicin in proliferating capillary cells and prostate cancer cells following ultrasound exposure

et al. 2011

View full text Add to dashboard Cite

Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment

Cited by 77 publications

References 132 publications

Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

In vitro study of ultrasound and different-concentration glycerol–induced changes in human skin optical attenuation assessed with optical coherence tomography

Increased accumulation of paclitaxel and doxorubicin in proliferating capillary cells and prostate cancer cells following ultrasound exposure

Contact Info

Product

Resources

About