Ultrasonic technologies in imaging and drug delivery

Ho, Yi-Ju; Huang, Chih-Chung; Fan, Chih‐Peng; Liu, Hao-Li; Yeh, Chih Kuang

doi:10.1007/s00018-021-03904-9

Cited by 20 publications

(15 citation statements)

References 240 publications

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“…HFUS is the basis for other imaging technology, including color and power doppler, ultrasound elastography, contrast enhanced ultrasound and so on. Doppler ultrasound is based on the principle that the transducer and the reflector of the sound wave are moving with respect to each other (Ho et al, 2021). Color and power doppler are used to evaluate the Chiang et al, 2014;Fang et al, 2017;Heng et al, 2017;Mustak et al, 2018)…”

Section: The Basic Principles Of High-frequency Ultrasound Imagingmentioning

confidence: 99%

“…The characteristics and indications of these technologies are listed in Table 1. (Kunzi-Rapp et al, 2006;Lee J.-N. et al, 2008;Koehler et al, 2008;Kuhn and Angehrn, 2009;Ardigo et al, 2010;Zhao et al, 2010;Lai and Xu, 2011;Lee et al, 2011;Kleinerman et al, 2012;De Pasquale et al, 2013;Chiang et al, 2014;Lallas et al, 2014;Lin et al, 2015;Sugata et al, 2015;Trojahn et al, 2015;Kim et al, 2016;Porto and Ozog, 2016;Scotto di Santolo et al, 2016;Heng et al, 2017;Manfredini et al, 2017;Su and Zhou, 2017;Sylwia and Krzysztof, 2017;Mustak et al, 2018;Ho et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Emerging High-Frequency Ultrasound Imaging in Medical Cosmetology

Yaping

et al. 2022

Front. Physiol.

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Cosmetic skin diseases are a part of many dermatological concerns brought up by patients, which negatively affect mental health and quality of life. Imaging technology has an established role in the diagnosis of cosmetic skin diseases by recognizing information on deep skin lesions. Due to the complex physiological and pathological nature of cosmetic skin diseases, the diagnostic imaging performance varies greatly. Developing noninvasive technology models with wide applicability, particularly high-frequency ultrasound (HFUS), which is able to achieve high-resolution imaging of the skin from the stratum corneum down to the deep fascia, is of great significance to medical cosmetology. To explore the great potential of HFUS in cosmetic skin diseases, a narrative review of literature from PubMed and Web of Science published between 1985 and 2022 was conducted. This narrative review focuses on the progression of HFUS imaging in medical cosmetology, especially on its promising application in the quantitative evaluation and differential diagnosis of cutaneous pathological scar, port wine stain (PWS), acne, skin aging, and other cosmetic applications.

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Section: The Basic Principles Of High-frequency Ultrasound Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emerging High-Frequency Ultrasound Imaging in Medical Cosmetology

Yaping

et al. 2022

Front. Physiol.

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“…Ultrasound (US) imaging is one of the frontline diagnostic tools in the clinic. Microbubbles (MBs) are used as an US contrast agent to provide functional information in high-contrast microvascular perfusion imaging [ 13 ]. In addition to applications in diagnostic imaging, MBs can also be used to carry therapeutic drugs, genes, or gas for local release triggered by focused US stimulation [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Overcoming Hypoxia-Induced Drug Resistance via Promotion of Drug Uptake and Reoxygenation by Acousto–Mechanical Oxygen Delivery

Thảo

Yeh

2022

Pharmaceutics

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Hypoxia-induced drug resistance (HDR) is a critical issue in cancer therapy. The presence of hypoxic tumor cells impedes drug uptake and reduces the cytotoxicity of chemotherapeutic drugs, leading to HDR and increasing the probability of tumor recurrence and metastasis. Microbubbles, which are used as an ultrasound contrast agent and drug/gas carrier, can locally deliver drugs/gas and produce an acousto–mechanical effect to enhance cell permeability under ultrasound sonication. The present study applied oxygen-loaded microbubbles (OMBs) to evaluate the mechanisms of overcoming HDR via promotion of drug uptake and reoxygenation. A hypoxic mouse prostate tumor cell model was established by hypoxic incubation for 4 h. After OMB treatment, the permeability of HDR cells was enhanced by 23 ± 5% and doxorubicin uptake was increased by 11 ± 7%. The 61 ± 14% reoxygenation of HDR cells increased the cytotoxicity of doxorubicin from 18 ± 4% to 58 ± 6%. In combination treatment with OMB and doxorubicin, the relative contributions of uptake promotion and reoxygenation towards overcoming HDR were 11 ± 7% and 28 ± 10%, respectively. Our study demonstrated that reoxygenation of hypoxic conditions is a critical mechanism in the inhibition of HDR and enhancing the outcome of OMB treatment.

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“…28,29 Accordingly, US stimulation can cause the liquid core of these droplets to vaporize due to ultrasound wave-associated pressure variations, thereby converting these droplets into gas bubbles. 30 With regard to MBs, droplets are more stable and can more readily be incorporated into nanoparticles (NPs). 31 When NPs are <350 nm in diameter, they can diffuse through pores present within the biofilm network.…”

Section: Introductionmentioning

confidence: 99%

“…Perfluoropentane (PFP) liquid droplets exhibit a very low boiling point so that they can readily reach a superheated state amenable to subsequent vaporization. , Accordingly, US stimulation can cause the liquid core of these droplets to vaporize due to ultrasound wave-associated pressure variations, thereby converting these droplets into gas bubbles . With regard to MBs, droplets are more stable and can more readily be incorporated into nanoparticles (NPs) .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Activatable Phase-Shift Nanoparticle as a Targeting Antibacterial Agent for Efficient Eradication ofPseudomonas aeruginosaBiofilms

Xin

Zhang

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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Biofilms are physical barriers composed of extracellular polymeric substances (EPS) that enable planktonic bacteria to resist host responses and antibacterial treatments, complicating efforts to clear bacteria such as Pseudomonas aeruginosa (P. aeruginosa) and thereby contributing to persistently chronic infections. As such, it is critical to develop a robust antimicrobial strategy capable of effectively eradicating P. aeruginosa biofilms and to further address aggressive clinical infection. In this study, ultrasound-activatable targeted nanoparticles were designed by using poly(lactic-co-glycolic acid) (PLGA) nanoparticles to encapsulate phase-transformable perfluoropentane (PFP) and the antibiotic meropenem via a double emulsion approach, followed by conjugation with anti-P. aeruginosa antibodies. In this strategy, ultrasound exposure can trigger PFP to produce microbubbles, inducing ultrasonic cavitation effects that can disrupt EPS components and allow nanoparticles to release meropenem to kill P. aeruginosa directly and accelerate the associated wound healing. These nanoparticles eradicated biofilms effectively and cleared bacteria in vitro as well as exhibited potent anti-infective activity in vivo. In summary, this study demonstrates the efficacy of a sonobactericidal strategy as a means of effectively and reliably eliminating biofilms.

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Ultrasonic technologies in imaging and drug delivery

Cited by 20 publications

References 240 publications

Emerging High-Frequency Ultrasound Imaging in Medical Cosmetology

Emerging High-Frequency Ultrasound Imaging in Medical Cosmetology

Overcoming Hypoxia-Induced Drug Resistance via Promotion of Drug Uptake and Reoxygenation by Acousto–Mechanical Oxygen Delivery

Ultrasound-Activatable Phase-Shift Nanoparticle as a Targeting Antibacterial Agent for Efficient Eradication ofPseudomonas aeruginosaBiofilms

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