Ultrasonication: the way to achieve antimutagenic effect of carboxymethyl-chitin–glucan by oral administration

Chorvatovičová, Darina; Machová, Eva; Šandula, J.

doi:10.1016/s1383-5718(97)00176-9

Cited by 27 publications

(18 citation statements)

References 24 publications

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“…Many of these polysaccharides were obtained from sources such as mushrooms that contain ␤-glucans [31][32][33] with similar structural features to botryosphaeran. Some studies have also involved isolated glucans from the cell wall of yeasts, S. cerevisiae [34] and Candida albicans [35], but few studies have reported the EPS from submerged fermentation [36,37], as is the case with botryosphaeran.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anticlastogenic activity exhibited by botryosphaeran, a new exopolysaccharide produced by Botryosphaeria rhodina MAMB-05

Miranda

Dekker

Serpeloni

et al. 2008

International Journal of Biological Macromolecules

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Section: Discussionmentioning

confidence: 99%

“…This can lead to their inactivity when administered orally because of reduced amounts of EPS in blood circulation [34]. To overcome this drawback, ultrasonication is often necessary to solubilise EPS [36], or water-soluble derivatives of EPS are prepared by derivatisation through carboxymethylation or sulfation [36,47].…”

Section: Discussionmentioning

confidence: 99%

Anticlastogenic activity exhibited by botryosphaeran, a new exopolysaccharide produced by Botryosphaeria rhodina MAMB-05

Miranda

Dekker

Serpeloni

et al. 2008

International Journal of Biological Macromolecules

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“…These radicals enhance the damage to DNA and other macromolecules, which increase the risk of cancer (Cherry, 2002). Chorvatovicova et al (1996 and1998) and Chorvatovicova and Sandula (1995) carried out a series of experiments concerning the anti-clastogenic effect of D-glucan on animals treated with strong mutagen they confirmed the same level of protection whether injected i.p. or intra venous.…”

Section: Discussionmentioning

confidence: 69%

Genetic Protective Role of D-Glucan against Oxidative Stress Induced by Mitomycin and Gamma-Radiation Exposure in Male Albino Rats

2013

Egypt. J. Rad.Sci.

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“…Segundo Chorvatovicová et al (1998) seria importante também estudar nestas terapias a administração concomitante da β-glucana e do quimioterápico, ciclofosfamida, para que se demonstrasse a possibilidade daquela em diminuir os efeitos adversos da quimioterapia. No entanto, ainda são muito controversos os princípios moleculares e bioquímicos que envolvem a atividade antitumoral, antimutagênica, imunoestimulatória e quimiopreventivas das diferentes β-glucanas (Saitô et al, 1991;Kishida et al, 1992;Demleitner et al, 1992).…”

Section: Discussionunclassified

Avaliação da mutagenicidade e antimutagenicidade de um biopolímero extraído do microorganismo Agrobacterium radiobacter em camundongos Swiss

Primo¹,

Calliari²,

Castro-Gómez³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:A presente pesquisa avaliou a ação mutagênica e antimutagênica de um biopolímero de glucose extraído da Agrobacterium radiobacter (Biopolímero de Agrobacterium radiobacter). O experimento foi realizado com camundongos Swiss machos divididos em oito grupos. O tratamento com o biopolímero foi realizado por gavage em dose única concomitante a uma dose de solução tampão fosfato nos grupos de avaliação da mutagenicidade, ou ao agente indutor de danos no DNA, ciclofosfamida, na concentração de 50 mg/kg (peso corpóreo -p.c.), nos grupos de avaliação da antimutagenicidade. Utilizou-se o teste de micronúcleo em sangue periférico e a coleta de sangue foi realizada 24 e 48 h após a aplicação das substâncias-teste. A análise estatística demonstrou que o biopolímero não possui atividade mutagênica e que é efetivo em prevenir danos no DNA. As porcentagens de redução de danos nos grupos de antimutagenicidade foram de 83,9%, 89,1% e 103,1% em 24 h e 101,24%, 98,14% e 120,64% em 48 h para as doses de 75, 150 e 300mg/kg (p.c.), respectivamente. A alta porcentagem de redução de danos associada à ausência de efeitos mutagênicos indica, além da atividade quimioprotetora, a possibilidade do biopolímero ser um alimento funcional candidato à utilização como co-adjuvante na quimioterapia para prevenir efeitos colaterais.Unitermos: Curdlana, biopolímero, Agrobacterium radiobacter, β-glucana, antimutagenicidade, camundongos Swiss.ABSTRACT: "Assessment of mutagenicity and antimutagenicity of a biopolymer extracted from the microorganism Agrobacterium radiobacter in mice." This study evaluated the mutagenic and ant mutagenic action of a biopolymer of glucose extracted from Agrobacterium radiobacter (Biopolymer of Agrobacterium radiobacter). The experiment was conducted with Swiss male mice divided into eight groups. Treatment with the biopolymer was performed in a single dose by gavage at a dose of concomitant phosphate buffer groups in the evaluation of mutagenicity, or the agent of inducing DNA damage, cyclophosphamide, the concentration of 50 mg/kg (body weight --b.w.), in groups of assessment ant mutagenic. We used the micronucleus test in peripheral blood. The blood sample was held 24 and 48 h after application of the test substances. Statistical analysis showed that the biopolymer has no mutagenic activity and it is effective in preventing damage to DNA. The percentages of damage reduction in groups of ant mutagenic were 83.9%, 89.1% and 103.1% in 24 h and 101.24%, 98.14% and 120.64% at doses of 48 to 75, 150 and 300 mg/kg (b.w.) respectively. The high percentage of damage reduction associated with the absence of mutagenic effects indicates the possibility of biopolymer chemoprotection action. It can also be considered a functional food candidate to be used as co-adjuvant chemotherapy to prevent side effects.

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Ultrasonication: the way to achieve antimutagenic effect of carboxymethyl-chitin–glucan by oral administration

Cited by 27 publications

References 24 publications

Anticlastogenic activity exhibited by botryosphaeran, a new exopolysaccharide produced by Botryosphaeria rhodina MAMB-05

Anticlastogenic activity exhibited by botryosphaeran, a new exopolysaccharide produced by Botryosphaeria rhodina MAMB-05

Genetic Protective Role of D-Glucan against Oxidative Stress Induced by Mitomycin and Gamma-Radiation Exposure in Male Albino Rats

Avaliação da mutagenicidade e antimutagenicidade de um biopolímero extraído do microorganismo Agrobacterium radiobacter em camundongos Swiss

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