Ultrasound

Tognetti, Linda; Liso, Flavio Giulio; Nazzaro, Gianluca; Provvidenziale, Luca; Piano, Enresto De; Carraro, Andrea; Perrot, Jean

doi:10.1007/978-3-030-45351-0_21

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Early reports of ultrasound in CTCL date back to the late 1990s. However, until recently its clinical utility was limited by low-frequency transducers lacking adequate resolution [ 8 , 11 , 12 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Morphologic Features of Cutaneous T-Cell Lymphomas Using Dermoscopy and High Frequency Ultrasound

Wohlmuth-Wieser

Ramjist

Shear

et al. 2020

JCM

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The diagnosis of cutaneous T-cell lymphomas (CTCL) is frequently delayed by a median of three years and requires the clinical evaluation of an experienced dermatologist and a confirmatory skin biopsy. Dermoscopy and high-frequency ultrasound (HFUS) represent two non-invasive diagnostic tools. While dermoscopy is inexpensive and widely used for the diagnosis of melanoma and non-melanoma skin cancers, HFUS of skin lymphomas represents a novel diagnostic approach that is not yet implemented in the routine dermatologic practice. The aim of our study was to prospectively assess skin lesions of patients with either CTCL patches or plaques with dermoscopy and HFUS and to compare the findings with atopic dermatitis (AD) and psoriasis. Thirteen patients with an established diagnosis of CTCL, psoriasis, or AD were studied: Dermoscopy features including spermatozoa-like structures and the presence of white scales could assist in differentiating between early-stage CTCL and AD. HFUS measurements of the skin thickness indicated increased epidermal-, thickness in CTCL, and psoriasis compared with AD. Our results support the use of dermoscopy as a useful tool to diagnose CTCL. HFUS could augment the dermatologic assessment, but further studies will be needed to define standardized parameters.

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Section: Discussionmentioning

confidence: 99%

Morphologic Features of Cutaneous T-Cell Lymphomas Using Dermoscopy and High Frequency Ultrasound

Wohlmuth-Wieser

Ramjist

Shear

et al. 2020

JCM

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“…2 , 3 ) along with signs of inflammation of the hypodermis and dermis (e.g., tissue density, fibrosis, vascular flow). 30 , 31 , 32 , 33 …”

Section: Commentmentioning

confidence: 99%

UVA‐1 phototherapy as adjuvant treatment for eosinophilic fasciitis: in vitro and in vivo functional characterization

et al. 2021

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Introduction Eosinophilic fasciitis (EF) is a rare autoimmune disease causing progressive induration of dermal, hypodermal, and muscularis fascia. The exact pathogenesis is yet to be fully understood, and a validated therapy protocol still lacks. We here aimed to realize a clinical-functional characterization of these patients.Materials and methods A total of eight patients (five males, 45 years average) were treated with adjuvant high-dose UVA-1 phototherapy (90 J/cm), after having received the standard systemic immunosuppressive protocol (oral methylprednisolone switched to methotrexate). Body lesion mapping, Localized Scleroderma Assessment Tool (LoSCAT), Dermatology Life Quality Index (DLQI), High-Resolution Ultrasound (HRUS) (13-17MHz), and ultra HRUS (55-70 MHz) were performed at each examination time taking specific anatomical points. Gene expression analysis at a molecular level and in vitro UVA-1 irradiation was realized on lesional fibroblasts primary cultures. ResultsThe LoSCAT and the DLQI showed to decrease significantly starting from the last UVA-1 session. A significant reduction in muscularis fascia thickness (À50% on average) was estimated starting from 3 months after the last UVA-1 session and maintained up to 12 months follow-up. Tissues was detected by HRUS. The UVA-1 in vitro irradiation of lesional skin sites cells appeared not to affect their viability. Molecular genes analysis revealed a significant reduction of IL-1ß and of TGF-ß genes after phototherapy, while MMPs 1,2,9 gene expression was enhanced.Comment These preliminary in vivo and in vitro findings suggest that UVA-1 phototherapy is a safe and useful adjuvant therapy able to elicit anti-inflammatory effects and stimulate tissue matrix digestion and remodeling at lesional sites.

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Role of ultra-high-frequency ultrasound in the diagnosis and management of basal cell carcinoma: pilot study based on 117 cases

Chauvel-Picard¹,

Tognetti

Cinotti

et al. 2023

Clinical and Experimental Dermatology

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Background Ultrasound imaging has recently benefited from the introduction of a new 70 MHz transducer able to provide high-resolution images, i.e.: ultra-high-frequency ultrasound (UHFUS). Objectives To study the morphological features of Basal Cell Carcinoma (BCC) and measure BCC thickness by means of UHFUS examination. Methods This retrospective multicentric study included 171 consecutive patients that underwent UHFUS examination between November 2018 and May 2019 for suspeted BCC. Diagnosis was confirmed by histopathology. A series of morphologic parameters including echogenicity, structure, borders, shape composition (i.e., presence of intralesional structures) were investigated along with objective measurements such as thickness (i.e., maximum distance between the surface of the epidermis and the deepest part of the tumor) and wideness. Results A total of 117 BCC of superficial (n = 13; 11.1%), nodular (n = 64; 54.5%), infiltrative (n = 17; 14.5%), mixed subtype (n = 18; 16.1%) and other subtypes (n = 2; 1.8%) were examined. The most frequently observed UHFUS parameters included: hypoechoic signal (80/117, 68.4%, p < 0.0001), homogeneous structure (76/117, 65%, p = 0.012), well-defined borders (77/117, 65.8%, p = 0.0006) and elongated shape (71/117, 60.7%, p < 0.0001). An excellent correlation was found between the BCC thickness measured by UHFUS and the value estimated by histology (interclass correlation – ICC > 0.8). Conclusions UHFUS is a new rapid and easy non-invasive skin imaging technique able to provide data on the dimension and morphology of BCC in real-time and at bed-site. These characteristics makes UHFUS useful in a plethora of possible application, ranging from the pre-surgical mapping to the detection of disease recurrence to the treatment monitoring.

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Ultrasound

Cited by 4 publications

References 21 publications

Morphologic Features of Cutaneous T-Cell Lymphomas Using Dermoscopy and High Frequency Ultrasound

Morphologic Features of Cutaneous T-Cell Lymphomas Using Dermoscopy and High Frequency Ultrasound

UVA‐1 phototherapy as adjuvant treatment for eosinophilic fasciitis: in vitro and in vivo functional characterization

Role of ultra-high-frequency ultrasound in the diagnosis and management of basal cell carcinoma: pilot study based on 117 cases

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