Ultrasound-assessed visceral fat and associations with glucose homeostasis and cardiovascular risk in clinical practice

Bellan, Mattia; Menegatti, Mirta; Ferrari, Carina; Gp, Carnevale Schianca

doi:10.1016/j.numecd.2018.01.006

Cited by 4 publications

(6 citation statements)

References 30 publications

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“…Notably, the feasibility and superior use of ultrasound‐based prediction of CMD risk factors have also been demonstrated in clinical settings. In a Metabolic Disorders Clinic in Italy, ultrasound‐derived assessments of IAT outperformed BMI in terms of predicting intima‐media thickness, Framingham Risk score, and vascular age 84 . Collectively, ultrasound‐based assessments of central adiposity can offer important, and compared to anthropometry, often superior reflections of CMD risk in a variety of populations and within both research and clinical settings.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound‐based measurement of central adiposity: Key considerations and guidelines

Zieff,

Cornwall,

Blue

et al. 2024

Obesity Reviews

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SummaryCentral adiposity, which is visceral and subcutaneous adiposity in the abdominal region, is a known risk factor for developing chronic cardiometabolic diseases. Central adiposity can be measured relatively inexpensively using ultrasound. Ultrasound has been shown to be precise and reliable, with measurement accuracy comparable to computed tomography and magnetic resonance. Despite the advantages conferred by ultrasound, widespread adoption has been hindered by lack of reliable standard operating procedures. To consolidate the literature and bring clarity to the use of ultrasound‐derived measures of central adiposity, this review outlines (i) the [patho]physiological importance of central adiposity to cardiometabolic disease risk; (ii) an overview of the history and main technical aspects of ultrasound methodology; (iii) key measurement considerations, including transducer selection, subject preparation, image acquisition, image analysis, and operator training; and (iv) guidelines for standardized ultrasound protocols for measuring central adiposity.

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Section: Discussionmentioning

confidence: 99%

Ultrasound‐based measurement of central adiposity: Key considerations and guidelines

Zieff,

Cornwall,

Blue

et al. 2024

Obesity Reviews

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“…Waist circumference (WC) is often used as raw measurement of abdominal fat, however this evaluation system is unable to separate the effect of VAT from that of SAT (17), and lacks in accuracy as regards its correlation with cardiovascular (CV) risk stratification, as described by several authors (18)(19)(20)(21). A further limitation of the WC is that the use of this measure in isolation may underestimate or overestimate the health risks for tall and short individuals with similar WCs, because there is relatively strong evidence of an inverse association between height and health risks (22)(23)(24).…”

Section: Abdominal Fat Compartmentsmentioning

confidence: 99%

“…The adipose tissue located inside the abdomen and the thorax, known as VAT, has been reported as the most dangerous, being the major determinant of insulin resistance (IR), glucose intolerance, dyslipidemia, atherogenic lipid profile, endothelial damage and thrombophilia, that are all known predictors of CV risk (18), as well as its increase is associated with cognitive decrements (43).…”

Section: Clinical Significancementioning

confidence: 99%

“…Moreover, VAT correlates equally or better than WC with clinical parameters, except for high blood pressure and low HDL (45). In 2018, Bellan et al (18) found that VAT was strongly associated with BMI and WC over the full spectrum of BMI categories when measuring IAFT by US, although the strength of these associations was strong in obese patients and weak in subjects of normal weight. Moreover, the same research group evaluated that, by adding to the model the estimate of the VAT by ultrasound in relation to the BMI alone, a better prediction of the Framingham score, the vascular age and the homeostatic model assessment (HOMA)-IR can be obtained (17).…”

Section: Clinical Significancementioning

confidence: 99%

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Ultrasound imaging, a stethoscope for body composition assessment

Ponti

Cinque

Fazio

et al. 2020

Quant Imaging Med Surg

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Dysregulation of the human's energy balance, mediated by non-performing endocrine organs (liver, skeletal muscle and adipose tissue, above all), can be related to human metabolic disorders characterized by an impaired body composition (BC), such as obesity and sarcopenia. While it is possible to monitor the BC and its variations at different levels, the tissue-organ composition studies have been proven to provide the most clinically applicable information. Ultrasonography (US), a fast, non-invasive, low-cost and widely available technique, holds great potential in the study of BC, as it can directly measure muscles, organs, visceral and subcutaneous fat tissue in different sections of the abdomen and body, overcoming some limits of anthropometric evaluation and other imaging techniques. Purpose of this review article is to explore the technical aspects and the applied methods of US examination to assess the potential clinical role of this technique in the context of BC characterization, investigating four pivotal topics [abdominal fat compartments, subcutaneous adipose tissue (SAT), skeletal muscle, liver].

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“…Hyperlipidemia is among the key risk factors for cardio-vascular diseases (CVD), inducing essential hypertension (EHT), coronary heart disease (CHD), heart failure, atherosclerosis (AS), and sudden cardiac death (SCD). Several studies [1,2,3,4,5] have provided evidence that low-density lipoprotein cholesterol (LDL-c) has been considered as the main risk factor of CHD and AS [6,7], and the increased circulating levels of triglycerides (TG) show a significant influence on CHD and AS [8,9]. Therefore, it is quite beneficial to research and explore anti-hypolipidemic agents that could modulate the dysregulation of lipid metabolism and decrease the elevated levels of serum TG [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and In Vitro Evaluation of Caffeoylquinic Acid Derivatives as Potential Hypolipidemic Agents

et al. 2019

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A series of novel caffeoylquinic acid derivatives of chlorogenic acid have been designed and synthesized. Biological evaluation indicated that several synthesized derivatives exhibited moderate to good lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives 3d, 3g, 4c and 4d exhibited more potential lipid-lowering effect than the positive control simvastatin and chlorogenic acid. Further studies on the mechanism of 3d, 3g, 4c and 4d revealed that the lipid-lowering effects were related to their regulation of TG levels and merit further investigation.

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Ultrasound-assessed visceral fat and associations with glucose homeostasis and cardiovascular risk in clinical practice

Cited by 4 publications

References 30 publications

Ultrasound‐based measurement of central adiposity: Key considerations and guidelines

Ultrasound‐based measurement of central adiposity: Key considerations and guidelines

Ultrasound imaging, a stethoscope for body composition assessment

Synthesis and In Vitro Evaluation of Caffeoylquinic Acid Derivatives as Potential Hypolipidemic Agents

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