Ultrasound-Assisted Extraction of Flavonoids from Potentilla fruticosa L. Using Natural Deep Eutectic Solvents

Xue, He; Li, Jinping; Wang, Guiyao; Zuo, Wenming; Zeng, Yang; Liu, Likuan

doi:10.3390/molecules27185794

Cited by 14 publications

(8 citation statements)

References 53 publications

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“…This result is aligned with the fact that bark is known to have a higher native concentration of polyphenols [ 3 ]. Overall, data suggest that DESs mixtures are an interesting alternative to traditional chemical solvents for the extraction of polyphenols [ 38 , 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Polyphenols from Maritime Pine Residues with Deep Eutectic Solvents

Duarte

Gomes

Aliaño-González

et al. 2022

Foods

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Deep eutectic solvents represent an important alternative in the field of green solvents due to their low volatility, non-toxicity, and low synthesis cost. In the present investigation, we propose the production of enriched polyphenolic extracts from maritime pine forest residues via an ultrasound-assisted approach. A Box–Behnken experimental design with a response surface methodology was used with six variables to be optimized: solid-to-solvent ratio, water percentage, temperature and time of extraction, amplitude, and catalyst concentration. The mixture of levulinic and formic acids achieved the highest extraction yield of polyphenols from pine needle and bark biomass. In addition, the solid-to-solvent ratio was found to be the only influential variable in the extraction (p-value: 0.0000). The optimal conditions were established as: 0.1 g of sample in 10 mL of LA:FA (70:30%, v/v) with 0% water and 0 M H2SO4 heated to 30 °C and extracted during 40 min with an ultrasound amplitude of 80% at 37 kHz. The bioactive properties of polyphenol-enriched extracts have been proven with significant antioxidant (45.90 ± 2.10 and 66.96 ± 2.75 mg Trolox equivalents/g dw) and antimicrobial activities. The possibility to recycle and reuse the solvent was also demonstrated; levulinic acid was successfully recovered from the extracts and reused in novel extractions on pine residues. This research shows an important alternative to obtaining polyphenol-enriched extracts from forest residues that are commonly discarded without any clear application, thus opening an important window toward the valorization of such residues.

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Section: Resultsmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Polyphenols from Maritime Pine Residues with Deep Eutectic Solvents

Duarte

Gomes

Aliaño-González

et al. 2022

Foods

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“…The extraction efficiency of the DES-based UAE method is due to cavitation bubbles in the DESs, and the ultrasonic wave passage produces damage in the plant cell wall, causing the release of cell content into the medium, which significantly accelerates the extraction process, decreasing extraction time, and increases extraction yield of flavonoids [81]. Xue et al prepared eight NADESs to extract flavonoids from PFL with the UAE method, and the optimal extraction conditions (40:1 mL/g of solvent/solid ratio, 318 W of ultrasonic power, and 47 min of extraction time) were found with the maximum extraction yield, providing an example on the use of NADES for replacing traditional solvents and enabling efficient extraction [82]. It was found that the extraction ability of NADESs was significantly higher than that of traditional solvents, and the DES solution broke the cell structure more effectively and promoted the extraction solution to break through the barrier of the cell walls with the help of ultrasound.…”

Section: Uae Of Flavonoids Using Dessmentioning

confidence: 99%

Application of deep eutectic solvents on extraction of flavonoids

Hao,

Pei,

Huang

et al. 2024

J of Separation Science

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Deep eutectic solvents (DESs), as a new type of eco‐friendly solvent, have attracted increasing attention on the extraction and separation of flavonoid compounds from various samples, owing to their excellent properties such as biodegradability and ease of handling with very low toxicity. This article provides a status review of the applications of DESs in the extraction of flavonoids, including the introduction of flavonoid compounds, the properties and superiority of DESs, and extraction methods (ultrasonic‐assisted extraction, heating reflux extraction, matrix solid‐phase dispersion, and solid‐phase extraction). Finally, prospects and challenges in the application of DESs on extraction and separation are extensively elucidated and critically reviewed.

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“…They have very good antioxidative and antimicrobial properties, which makes them promising natural preservatives. Examples of flavonoid extraction with DESs from plant material are presented in Table . ,,,,,,,− …”

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Wawoczny

Gillner

2023

J. Agric. Food Chem.

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There is growing interest in reducing the number of synthetic products or additives and replacing them with natural ones. The pharmaceutical, cosmetic, and food industries are especially focused on natural and bioactive chemicals isolated from plants or microorganisms. The main challenge here is to develop efficient and ecological methods for their isolation. According to the strategies and rules of sustainable development and green chemistry, green solvents and environmentally friendly technologies must be used. The application of deep eutectic solvents as efficient and biodegradable solvents seems to be a promising alternative to traditional methods. They are classified as being green and ecological but, most importantly, very efficient extraction media compared to organic solvents. The aim of this review is to present the recent findings on green extraction, as well as the biological activities and the possible applications of natural plant ingredients, namely, phenolics, flavonoids, terpenes, saponins, and some others. This paper thoroughly reviews modern, ecological, and efficient extraction methods with the use of deep eutectic solvents (DESs). The newest findings, as well as the factors influencing the efficiency of extraction, such as water content, and hydrogen bond donor and acceptor types, as well as the extraction systems, are also discussed. New solutions to the major problem of separating DESs from the extract and for solvent recycling are also presented.

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Ultrasound-Assisted Extraction of Flavonoids from Potentilla fruticosa L. Using Natural Deep Eutectic Solvents

Cited by 14 publications

References 53 publications

Ultrasound-Assisted Extraction of Polyphenols from Maritime Pine Residues with Deep Eutectic Solvents

Ultrasound-Assisted Extraction of Polyphenols from Maritime Pine Residues with Deep Eutectic Solvents

Application of deep eutectic solvents on extraction of flavonoids

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

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