“…Later on a first, simple and convenient synthetic methodology has been reported by Radziszewski and japp for the synthesis of 2,4,5-tri phenyl imidazoles by using 1,2 dicarbonyl compounds, ammonia, various aldehydes [14]. Afterward several methods have been reported for the synthesis of tri-substituted imidazoles by cyclo condensation of 1,2 dicarbonyl compounds, various aromatic aldehydes and ammonium acetate using various catalysts such as NiCl 2 •6H 2 O/Al 2 O 3 [15], MoO 3 /SiO 2 [16], Polymer supported zinc chloride [17], trichloro isocyanuric acid (TCCA) [18] under reflux conditions and glyoxalic acid as catalyst under microwave conditions [19] and Zinc (II) (tetra (4-methylphenyl)) porphyrin [20], Magnetic Fe 3 O 4 nano particles [21], Sulfamic acid functionalized magnetic nano particles SA-MNP [22], Ionic liquid (EMIM)OAc [23], Zr(acac) 4 [24], ceric ammonium nitrate [25] as catalysts under ultra sound assisted conditions. In the same way several methods have been reported for the synthesis of tetra substituted imidazoles by cyclo condensation of 1,2 dicarbonyl compounds, various aromatic aldehydes, ammonium acetate and aromatic/aliphatic amines using various catalysts such as nano TiCl 4 •SiO 2 [26] [33] as catalyst under Ultra sound irradiation.…”