Ultrasound-assisted packed-bed extraction of hypericin from Hypericum perforatum L. and optimization by response surface methodology

Tahmasebi-Boldaji, Ramin; Hatamipour, Mohammad Sadegh; Khanahmadi, Morteza; Sadeh, Pegah; Najafipour, Iman

doi:10.1016/j.ultsonch.2019.05.018

Cited by 30 publications

(7 citation statements)

References 30 publications

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“…Furthermore, Adj R-Squared (Radj 2 ) was close to R 2 , implying reasonable adjustment of the model to the experimental data [46]. The "Lack of Fit F-value" of 0.13 implies the lack-of-fit was not significant relative to the pure error, indicating that the experimental error is very small and the suitability of the model to accurately predict variation [43,47]. The F value of the model was 117.59, which indicates that the model is extremely significant with a probability of 0.01%.…”

Section: Model Fittingmentioning

confidence: 84%

Optimization of Ultrasound Assisted Extraction (UAE) of Kinsenoside Compound from Anoectochilus roxburghii (Wall.) Lindl by Response Surface Methodology (RSM)

et al. 2020

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The purpose of this study was to establish an extraction method for the kinsenoside compound from the whole plant Anoectochilus roxburghii. Ultrasound assisted extraction (UAE) and Ultra-high performance liquid chromatography (UPLC) method were used to extract and determine the content of kinsenoside, while response surface method (RSM) was used to optimize the extraction process. The best possible range for methanol concentration (0–100%), the liquid-solid ratio (5:1–30:1 mL/g), ultrasonic power (240–540 W), duration of ultrasound (10–50 min), ultrasonic temperature (10–60 °C), and the number of extractions (1–4) were obtained according to the single factor experiments. Then, using the Box-Behnken design (BBD) of response surface analysis, the optimum extraction conditions were obtained with 16.33% methanol concentration, the liquid-solid ratio of 10.83:1 mL/g and 35.00 °C ultrasonic temperature. Under these conditions, kinsenoside extraction yield reached 32.24% dry weight. The best conditions were applied to determine the kinsenoside content in seven different cultivation ages in Anoectochilus roxburghii.

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Section: Model Fittingmentioning

confidence: 84%

Optimization of Ultrasound Assisted Extraction (UAE) of Kinsenoside Compound from Anoectochilus roxburghii (Wall.) Lindl by Response Surface Methodology (RSM)

et al. 2020

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“…Adjusted was determined to be 0.9862 and 0.9546 for nitrate and phosphate removal, respectively, and these values are close to 1. The statistical suitability of the model is determined from the closeness of the R 2 Adjusted values to the R 2 [43]. The value of adequate precision of 44.905 and 27.433 (which are greater than 4), for nitrate removal and phosphate removal, respectively, indicates an adequate signal.…”

Section: Response Surface Methodologymentioning

confidence: 99%

Activated carbon produced from Glycyrrhiza glabra residue for the adsorption of nitrate and phosphate: batch and fixed-bed column studies

et al. 2020

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In the present study, Glycyrrhiza glabra residues (GGR) were used for the preparation of activated carbon, with a surface area of 959.22 m 2 g −1 . Activated carbon was prepared through chemical activation using ZnCl 2 at optimum carbonization temperature, and impregnation ratio for nitrate, and phosphate removal. The effect of contact time and adsorbent dosage on the removal efficiency was investigated, and the pseudo-second-order kinetic model correlated well with the adsorption data. The response surface methodology was applied for the determination of the effect of initial concentration, pH, and temperature and their interaction on the removal efficiency in the batch adsorption system. The Langmuir isotherm generated a satisfactory fit with the experimental data, and the maximum adsorption capacity was 142.5 mg g −1 at 308 K and 92.5 mg g −1 at 298 K for nitrate and phosphate removal, respectively. The high adsorption capacity reveals the applicability of the GGR activated carbon for nitrate and phosphate removal. Furthermore, the fixed-bed column adsorption studies were carried out, and the effect of flow rate and influent concentration on the behavior of the breakthrough curve was studied. The breakthrough time decreased by increasing the flow rate and inlet concentration. The Thomas and Yoon-Nelson models were suitable models for the design of GGR activated carbon fixed-bed column. The LUB of 0.44 cm and 4.35 cm was obtained for nitrate and phosphate with the inlet concentration of 20 mg L −1 and a flow rate of 40 mL min −1 , respectively. GGR is a new adsorbent that has not been previously utilized for adsorption of phosphate and nitrate.

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“…After cooling, the combined filtrates were concentrated using a rotary evaporator and then freeze-dried. The solvent choice and concentration were based on scientific literature data [19,30,39,42,43]. The extraction yield is expressed as the percentage of the total mass of the dry extract (M ext without water content) with respect to the mass of the raw material (M pv ) loaded onto to the flask for solvent extraction: Y% = (M ext /M pv ) × 100.…”

Section: Vegetal Samplesmentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of Ficus Elastica Roxb. Ex Hornem and Raphanus Sativus L. Selective Dry Extracts With Potential Antidiabetic Activity

Hilfi¹

2019

FARMACIA

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The aim of our study consisted in obtaining, phytochemical and antioxidant activity evaluation of two selective dry extracts from the leaves of Ficus elastica Roxb. ex Hornem and Raphanus sativus L., with potential use in metabolic diseases. The results of the phytochemical assessment of the two hydroethanolic dry extracts (the employed hydroethanolic mixture were: 70% ethanol (v/v) for Fici elastici folium and 50% ethanol (v/v) for Raphani sativi folium) indicated the following: Fici elastici extractum (FEE) -3.6140±0.4000 g% flavonoids expressed as hyperoside, 5.950 ± 0.3800 g% phenolcarboxylic acids expressed as chlorogenic acid, 13.3299 ± 0.1583 g% total phenolic compounds expressed as tannic acid; 2. Raphani sativi extractum (RSE) -6.7300 ± 0.6600 g% flavonoid expressed as hyperoside, 3.1263 ± 0.1500 g% phenolcarboxylic acids expressed as chlorogenic acid, 21.4175 ± 0.9454 g% total phenolic compounds expressed as tannic acid. The HPLC analysis confirmed the presence of apigenin-7-glucoside in Raphani sativi extractum. Evaluation of the antiradicalar activity of the dry extracts was determined by scavenger activity of free radicals, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) and by ferric reducing power method. The antioxidant activity was expressed as EC50 mg/mL. The following results were obtained: EC50 DPPH = 6.4166 ± 0.3329 mg/mL, EC50 ABTS = 0.0768 ± 0.0020 mg/mL, EC50 ferric reducing power = 0.4027 ± 0.0016 mg/mL (for FEE); EC50 DPPH = 7.5100 ± 0.1414 mg/mL, EC50 ABTS = 0.2611 ± 0.1893 mg/mL, EC50 ferric reducing power =1.3935 ± 0.0111 mg/mL (for RSE). RezumatScopul lucrării a constat în obţinerea, caracterizarea fitochimică şi evaluarea activităţii antioxidante a două extracte uscate, selective, obţinute din frunzele de Ficus elastica Roxb. ex Hornem şi Raphanus sativus L., cu potenţială activitate în tratamentul afecţiunilor metabolice. Extracte hidroalcoolice uscate (obţinute în etanol 70% pentru Fici elastici folium şi în etanol 50% pentru Raphani sativi folium) conţin: Fici elastici extractum (FEE) -3,6140 ± 0,4000 g% flavone exprimate în hiperozidă, 5,950 ± 0,3800 g% acizi fenol-carboxilici exprimați în acid clorogenic, 13,3299 ± 0,1583 g% polifenoli totali exprimaţi în acid tanic; Raphani sativi extractum (RSE) -6,7300 ± 0,6600 g% flavone exprimate în hiperozidă, 3,1263 ± 0,1500 g% acizi fenol-carboxilici exprimaţi în acid clorogenic, 21,4175 ± 0,9454 g% polifenoli totali exprimaţi în acid tanic. Analiza HPLC a evidenţiat prezenţa apigenin-7-glucozidei în RSE. Activitatea antioxidantă a extractelor a fost determinată pe baza capacităţii de scavenger a radicalilor liberi DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS•+ (acidul 2,2'-azinobis-3etilbenzotiazolin-6-sulfonic) şi pe baza capacităţii de reducere a ferului. Capacitate antioxidantă a fost evaluată pe baza EC50 (µg/mL). S-au obţinut următoarele rezultate: EC50 DPPH = 6,4166 ± 0,3329 mg/mL, EC50 ABTS = 0,0768 ± 0,0020 mg/mL, EC50 reducerea ferului = 0,4027 ± 0,0016 mg/mL (pentru FEE); EC...

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Ultrasound-assisted packed-bed extraction of hypericin from Hypericum perforatum L. and optimization by response surface methodology

Cited by 30 publications

References 30 publications

Optimization of Ultrasound Assisted Extraction (UAE) of Kinsenoside Compound from Anoectochilus roxburghii (Wall.) Lindl by Response Surface Methodology (RSM)

Optimization of Ultrasound Assisted Extraction (UAE) of Kinsenoside Compound from Anoectochilus roxburghii (Wall.) Lindl by Response Surface Methodology (RSM)

Activated carbon produced from Glycyrrhiza glabra residue for the adsorption of nitrate and phosphate: batch and fixed-bed column studies

Chemical Composition and Antioxidant Activity of Ficus Elastica Roxb. Ex Hornem and Raphanus Sativus L. Selective Dry Extracts With Potential Antidiabetic Activity

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