Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy

Hu, Jianjun; He, Jiangyi; Wang, Yunlong; Yang, Zhao; Fang, Kejing; Dong, Yan; Chen, Yanrong; Zhang, Yue; Zhang, Chi; Wang, Hongwei; Tan, Jun; Wang, Junyi; Zi, Ruiyang; Li, Chengxiang; Liang, Houjie; Guo, Yanli; Ou, Juanjuan

doi:10.1136/jitc-2021-003408

Cited by 19 publications

(18 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, the cavitation effect of ultrasound can also cause cell membrane cleavage and release of immunogenic DAMPs. Interestingly, it has been proved that ultrasonic cavitation can enhance the rate of ROS production and ICD induction ( 29 , 30 ). In recent years, several studies related to SDT have demonstrated that SDT induces immunogenic death of tumor cells as an “ in situ vaccine” that activates the body’s immune response against tumors and has been verified in vitro and in vivo ( 31 – 33 ).…”

Section: Main Mechanism Of Sdt Induction Icdmentioning

confidence: 99%

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Wang

Peng

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

Immunotherapy is widely regarded as a promising treatment for cancer. However, the immune effector phase suppression of tumor microenvironment (TME) and the generation of immune-related adverse events limit its application. Research indicates that sonodynamic therapy (SDT) can effectively activate antitumor immunity while killing tumor cells. SDT produces cytotoxic substances of tumors, and then cell apoptosis and immunogenic death occur by selectively activating the sonosensitizer under ultrasound. In recent years, various SDT alone as well as SDT in combination with other therapies have been developed to induce immunogenic cell death (ICD) and enhance immunotherapy. This paper overviews the research progress of SDT and nanotechnology in recent years, including the strategies involving SDT alone, SDT-based synergistic induction of antitumor immunity, and immunotherapy based on SDT for multimodal immunotherapy. Finally, the prospects and challenges of these SDT-based therapies in cancer immunotherapy are discussed.

show abstract

Section: Main Mechanism Of Sdt Induction Icdmentioning

confidence: 99%

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Wang

Peng

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…[40,53] Although delivery mechanism of UTMD/UTND is gradually clarified, the impact of UTMD/UTND on tumor immune microenvironment is still unclear. A study [54] found that ultrasound-stimulated nanobubbles (USNBs) could elicit c-e) The populations of GZMB + CD8 + T, IFN-𝛾 + CD8 + T, and PD1 + Tim3 + CD8 + T cells in different groups. Adapted with permission.…”

Section: Direct Effect Of Utmd/utnd On Immune Responsementioning

confidence: 99%

“…Although delivery mechanism of UTMD/UTND is gradually clarified, the impact of UTMD/UTND on tumor immune microenvironment is still unclear. A study [ 54 ] found that ultrasound‐stimulated nanobubbles (USNBs) could elicit cavitation effect, and subsequently induce tumor cell lysis with DAMPs releasing. These DAMPs act as “eat me” signals to recruit antigen‐presenting cells (APCs) to present dead cell‐associated antigens to T cells, thereby promote adaptive antitumor immune response, showing great promise in the immunotherapy for cancer treatment ( Figure a).…”

Section: Ultrasound Targeted Micro‐/nanobubble Destructionmentioning

confidence: 99%

See 1 more Smart Citation

Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy

Liang,

Qiao,

Qiu

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Due to the specific advantages of ultrasound (US) in therapeutic disease treatments, the unique therapeutic US technology has emerged. In addition to featuring a low‐invasive targeted cancer‐cell killing effect, the therapeutic US technology has been demonstrated to modulate the tumor immune landscape, amplify the therapeutic effect of other antitumor therapies, and induce immunosensitization of tumors to immunotherapy, shedding new light on the cancer treatment. Tremendous advances in nanotechnology are also expected to bring unprecedented benefits to enhancing the antitumor efficiency and immunological effects of therapeutic US, as well as therapeutic US‐derived bimodal and multimodal synergistic therapies. This comprehensive review summarizes the immunological effects induced by different therapeutic US technologies, including ultrasound‐mediated micro‐/nanobubble destruction (UTMD/UTND), sonodynamic therapy (SDT), and focused ultrasound (FUS), as well as the main underlying mechanisms involved. It is also discussed that the recent research progress of engineering intelligent nanoplatform in improving the antitumor efficiency of therapeutic US technologies. Finally, focusing on clinical translation, the key issues and challenges currently faced are summarized, and the prospects for promoting the clinical translation of these emerging nanomaterials and ultrasonic immunotherapy in the future are proposed.

show abstract

“…In a study by Hu et al (18), the authors compared the antitumor effect of ultrasound-stimulated nanobubbles alone and in combination with an anti-programmed cell death protein 1 (aPD-1) in RM1 (prostate cancer), MC38 (colon cancer), and B16 (melanoma) xenograft mouse models. They found that ultrasound-stimulated nanobubbles combined with aPD-1 induced tumor cell necrosis, significantly increased the release of DAMP and tumor antigen presentation, and promoted the invasion and antitumor activity of CD8+ T cells (Figure 3).…”

Section: Modulation Of Utmd On Tumor Immune Microenvironmentmentioning

confidence: 99%

Ultrasound-Targeted Microbubble Destruction: Modulation in the Tumor Microenvironment and Application in Tumor Immunotherapy

et al. 2022

View full text Add to dashboard Cite

Tumor immunotherapy has shown strong therapeutic potential for stimulating or reconstructing the immune system to control and kill tumor cells. It is a promising and effective anti-cancer treatment besides surgery, radiotherapy and chemotherapy. Presently, some immunotherapy methods have been approved for clinical application, and numerous others have demonstrated promising in vitro results and have entered clinical trial stages. Although immunotherapy has exhibited encouraging results in various cancer types, however, a large proportion of patients are limited from these benefits due to specific characteristics of the tumor microenvironment such as hypoxia, tumor vascular malformation and immune escape, and current limitations of immunotherapy such as off-target toxicity, insufficient drug penetration and accumulation and immune cell dysfunction. Ultrasound-target microbubble destruction (UTMD) treatment can help reduce immunotherapy-related adverse events. Using the ultrasonic cavitation effect of microstreaming, microjets and free radicals, UTMD can cause a series of changes in vascular endothelial cells, such as enhancing endothelial cells’ permeability, increasing intracellular calcium levels, regulating gene expression, and stimulating nitric oxide synthase activities. These effects have been shown to promote drug penetration, enhance blood perfusion, increase drug delivery and induce tumor cell death. UTMD, in combination with immunotherapy, has been used to treat melanoma, non-small cell lung cancer, bladder cancer, and ovarian cancer. In this review, we summarized the effects of UTMD on tumor angiogenesis and immune microenvironment, and discussed the application and progress of UTMD in tumor immunotherapy.

show abstract

Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy

Cited by 19 publications

References 46 publications

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy

Ultrasound-Targeted Microbubble Destruction: Modulation in the Tumor Microenvironment and Application in Tumor Immunotherapy

Contact Info

Product

Resources

About