Ultrasound-guided photoacoustic imaging: current state and future development

Bouchard, Richard R.; Sahin, Onur; Emelianov, Stanislav

doi:10.1109/tuffc.2014.2930

Cited by 86 publications

(69 citation statements)

References 180 publications

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“…Photoacoustic imaging has been widely studied fused with variable medical fields such as US and microscopy [26], [27]. Recently, Kang et al investigated PAI-visualized microcalcifications in breast tissues in a study which revealed the absorbance differences between microcalcifications and surrounding tissues [15], [28].…”

Section: Discussionmentioning

confidence: 99%

Ex Vivo Estimation of Photoacoustic Imaging for Detecting Thyroid Microcalcifications

et al. 2014

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BackgroundThe aim of this study was to evaluate the diagnostic utility of PAI at detecting thyroid microcalcifications at 700 nm laser wavelengths.MethodsThis study included 36 resected samples in 18 patients. To evaluate the PA manifestation of microcalcifications in PAI, gray level histogram and co-occurrence matrix (COM) texture parameters were extracted from the 3 fixed ROI US and PA images, respectively, per sample. We compared the textural parameters obtained from specimen PAIs between samples with punctate microcalcifications on specimen radiography and those without microcalcifications.ResultsOn specimen US, the mean value (2748.4±862.5) of samples with microcalcifications on specimen radiography was higher than that (1961.9±780.2) of those without microcalcifications (P = 0.007). However, there were no significant differences in textural parameters obtained from specimen PAIs between samples with punctate microcalcifications on specimen radiography and those without when applying both the mean value of the three slices of thyroid specimens and the value of the thyroid specimen slice which had the highest value of the mean values in specimen US.ConclusionPAI did not show significant PA contrast on thyroid microcalcifications indicating that the experimental setup and protocols should be enhanced, e.g., method of complete blood rejection from ex vivo specimens, the multi-wavelength spectroscopic PA imaging method which can solely extract the PA signal from microcalcifications even with high spectral interferences, or PA imaging with narrower slice thickness using 2-dimensional array transducer, etc.

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Section: Discussionmentioning

confidence: 99%

Ex Vivo Estimation of Photoacoustic Imaging for Detecting Thyroid Microcalcifications

et al. 2014

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“…101 Similarly, photonic-based cancer therapies, such as laser induced photodynamic therapy (PDT) 105,106 and photothermal therapy (PTT), 107 can also bene¯t from PAI, as PAI can monitor the drug distribution simultaneously during the therapy without the use of additional contrast agents. Furthermore, PAI can be combined with other imaging modalities, such as°uorescence imaging 81,92,108 and US imaging, 57,58,64,81,109 to provide complementary information and optimal image quality. Through PAI, minimally invasive onsite prostate cancer diagnosis with enhanced sensitivity and speci¯city may be achieved.…”

Section: Future Outlookmentioning

confidence: 99%

Photoacoustic imaging of prostate cancer

Yang

Xiang

2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a rapidly growing imaging modality with potential in medical diagnosis and therapy monitoring. This paper focuses on the techniques of prostate PAI and its potential applications in prostate cancer detection. Transurethral light delivery combined with transrectal ultrasound detection overcomes light scattering in the surrounding tissue and provides optimal photoacoustic signals while minimizing invasiveness. While label-free PAI based on endogenous contrast has promising potential for prostate cancer detection, exogenous contrast agents can further enhance the sensitivity and speci¯city of prostate cancer PAI. Further in vivo studies are required in order to achieve the translation of prostate PAI to clinical implementation. The minimal invasiveness, relatively low cost, high speci¯city and sensitivity, and real-time imaging capability are valuable advantages of PAI that may improve the current prostate cancer management in clinic.

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“…The illuminated tissue experiences thermal expansion, which in turn produces acoustic waves that are received by a conventional ultrasound array transducer, forming a map of optical absorption which can be used either independently or in conjunction with ultrasound [49]. Penetration depths in photoacoustic imaging are approximately 2 cm [50].…”

Section: High Resolution Vascular Imaging Technologiesmentioning

confidence: 99%

Acoustic angiography: a new high frequency contrast ultrasound technique for biomedical imaging

et al. 2016

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Acoustic Angiography is a new approach to high-resolution contrast enhanced ultrasound imaging enabled by ultrabroadband transducer designs. The high frequency imaging technique provides signal separation from tissue which does not produce significant harmonics in the same frequency range, as well as high resolution. This approach enables imaging of microvasculature in-vivo with high resolution and signal to noise, producing images that resemble x-ray angiography. Data shows that acoustic angiography can provide important information about the presence of disease based on vascular patterns, and may enable a new paradigm in medical imaging.

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Ultrasound-guided photoacoustic imaging: current state and future development

Cited by 86 publications

References 180 publications

Ex Vivo Estimation of Photoacoustic Imaging for Detecting Thyroid Microcalcifications

Ex Vivo Estimation of Photoacoustic Imaging for Detecting Thyroid Microcalcifications

Photoacoustic imaging of prostate cancer

Acoustic angiography: a new high frequency contrast ultrasound technique for biomedical imaging

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