Ultrasound‐Triggered Smart Drug Release from a Poly(dimethylsiloxane)– Mesoporous Silica Composite

Abstract

Ultrasound is used as an external trigger for the pulsatile release of the drug ibuprofen. The system is composed of mesoporous silica as the drug reservoir and poly(dimethylsiloxane) (PDMS) as an implantable body. This system could find use for in vivo delivery of drugs in response to changes in physiological conditions.

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

“…This polarity change provokes the opening of the gates of the mesoporous channels resulting in a release of drug molecules. Kim et al 159 reported a silica nanoparticle-based DDS that could be triggered by ultrasound. The system was composed of mesoporous silica as the drug reservoir and poly dimethylsiloxane (PDMS) as gatekeeper to suppress the initial fast release.…”

Triggered-release drug delivery nanosystems for cancer therapy by intravenous injection: where are we now?

“…The loaded drugs could be subsequently released after the collapse and transformation of calcium phosphate nanocarriers to pin-shaped crystallites [14]. Another controllable, smart, pulsatile ultrasonic-triggered drug-releasing system was constructed based on the poly (dimethylsiloxane)-mesoporous silica system, which greatly suppressed the 'burst effect' of traditional mesoporous silicabased DDSs [15].…”

Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules

“…However, development of such systems is currently heavily reliant on responsive polymeric materials [4,5] that are responsive, for example, to enzymes [6], light [7], temperature [8], calcium [9] and ultrasound [10]. Such systems usually incorporate responsive elements, e.g.…”