Ultrastructural, immunohistochemical and biochemical investigations of the rat liver exposed to experimental diabetes und acute hypoxia with and without application of Ginkgo extract

Welt, K; Weiss, J.; Martin, Roderick; Dettmer, D; Hermsdorf, Thomas; Asayama, Kohtaro; Meister, Sarah; Fitzl, G.

doi:10.1078/0940-2993-00337

Cited by 33 publications

(24 citation statements)

References 34 publications

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“…[16][17][18][19] In addition, increased lipid accumulation and decreased glycogen content are also seen in the liver cells. [16][17][18][19] b i o c h e m i c a l c h a n g e s…”

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

“…Under these conditions, steatosis and necroinflammatory mechanisms are difficult to observe. [15][16][17][18] Ultrastructurally, the rough endoplasmic reticulum is significantly reduced in diabetic patients in comparison with the smooth endoplasmic reticulum. 9 Moreover, DM causes a marked increase in mitochondrial volume fraction with highly diminished densities of mitochondrial cristae, pyknotic nuclei with damaged nuclear membranes and the extension of the perinuclear area [ Figure 2].…”

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

“…9 Moreover, DM causes a marked increase in mitochondrial volume fraction with highly diminished densities of mitochondrial cristae, pyknotic nuclei with damaged nuclear membranes and the extension of the perinuclear area [ Figure 2]. [16][17][18][19] In addition, increased lipid accumulation and decreased glycogen content are also seen in the liver cells. [16][17][18][19] b i o c h e m i c a l c h a n g e s…”

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

“…A combination of all of these processes causes massive tissue destruction in the liver. 16,29 However, the liver is equipped with potent antioxidants-such as superoxide dismutase (SOD), catalase (CAT) and the glutathione (GSH) enzyme family, including glutathione-S-transferases (GSTs) and glutathione peroxidases (GPXs)-so as not only to neutralise free radicals but also to protect the liver cells from oxidative damage. 30,31 Previous research has proven that a decrease in SOD and CAT activities within a hyperglycaemic state leads to an increase in ROS, which eventually contributes to oxidationinduced liver damage.…”

Section: Oxidative Stress-mediated Damagementioning

confidence: 99%

“…48 Vitamin E and betaine are just a few of the antioxidants which have shown good clinical implications in the reduction of liver disease severity and the protection of the liver from DM-induced damage [ Table 1]. 4,8,9,16,18,30,[55][56][57] …”

Section: Mitogen-activated Protein Kinasementioning

confidence: 99%

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Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Mohamed¹,

Nafizah²,

Zariyantey³

et al. 2016

SQUMJ

360

199

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Diabetes mellitus is a non-communicable disease that occurs in both developed and developing countries. This metabolic disease affects all systems in the body, including the liver. Hyperglycaemia, mainly caused by insulin resistance, affects the metabolism of lipids, carbohydrates and proteins and can lead to nonalcoholic fatty liver disease, which can further progress to non-alcoholic steatohepatitis, cirrhosis and, finally, hepatocellular carcinomas. The underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes. Significant involvement of pro-inflammatory cytokinesincluding interleukin (IL)-1β, IL-6 and tumour necrosis factor-α-exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.

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“…[16][17][18][19] In addition, increased lipid accumulation and decreased glycogen content are also seen in the liver cells. [16][17][18][19] b i o c h e m i c a l c h a n g e s…”

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

Section: Oxidative Stress-mediated Damagementioning

confidence: 99%

Section: Mitogen-activated Protein Kinasementioning

confidence: 99%

See 3 more Smart Citations

Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Mohamed¹,

Nafizah²,

Zariyantey³

et al. 2016

SQUMJ

360

199

View full text Add to dashboard Cite

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Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat

et al. 2010

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Rationale 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used recreational drug known to cause selective long-term serotonergic damage.Objectives The aim of this study was to characterize the ultrastructure of serotonergic pericarya and proximal neurites in the dorsal raphe nucleus as well as the ultrastructure of serotonergic axons in the frontal cortex of adolescent Dark Agouti rats 3 days after treatment with 15 mg/kg i.p. MDMA.Methods Light microscopic immunohistochemistry and pre-embedding immunoelectron microscopy with a novel tryptophan hydroxylase-2 (Tph2) specific antibody, as a marker of serotonergic structures.The high resolution version of the original images are available in the supplementary figures.Electronic supplementary material The online version of this article (

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Identification of Silver Nanoparticles in the Small Intestinal Mucosa, Liver, and Spleen of Rats by Transmission Electron Microscopy

et al. 2013

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The effects of water-dispersed Ag nanoparticles on the small intestinal mucosa, liver, and spleen of rats were studied by transmission electron microscopy. Acute experiments demonstrated penetration of Ag nanoparticles injected into the isolated intestinal loop into the intestinal mucosa, liver, and splenic tissues. Ultrastructural changes (lobed nucleus, megamitochondria) were found in the studied organs. These data indicated that injection of water-dispersed Ag nanoparticles into the gastrointestinal tract was followed by their penetration through the epithelium of the small intestinal mucosa into other organs, e.g. into the liver and spleen. This fact is essential for evaluation of potential risks of the nanoparticle effects on human health and environment.

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Ultrastructural, immunohistochemical and biochemical investigations of the rat liver exposed to experimental diabetes und acute hypoxia with and without application of Ginkgo extract

Cited by 33 publications

References 34 publications

Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat

Identification of Silver Nanoparticles in the Small Intestinal Mucosa, Liver, and Spleen of Rats by Transmission Electron Microscopy

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