The objective of this work was to investigate changes in the acoustic characteristics of micromachined transducers caused by acoustic cross-coupling between cells. We used hexagonal, polymer-based capacitive micromachined ultrasonic transducers (polyCMUTs) consisting of 127 cells connected in parallel. The distances between the cells were varied, while the cell dimensions and number of cells remained constant. The resulting changes in characteristics were evaluated in terms of peak frequency f pk , fractional bandwidth F BW , peak transmit sensitivity S pk and opening angle Φ t . The study relies on results from an analytic multicell model (MCM) which considers cross-coupling effects between cells through a mutual acoustic impedance matrix. The results are compared with finite element (FE) analyses and measurements on fabricated prototypes. The manufacturing processes used to produce the polyCMUT prototypes are explained in detail. We found significant changes in all acoustic characteristics: as cell spacing increases, f pk and Φ t decrease, while S pk gradually rises to about twice the initial value. The F BW varies due to the change in f pk , peaking at small to intermediate cell-to-cell distances. While both modeling approaches cover the general effects, discrepancies in comparison to the measurements were identified. The FE model provided better fits than the analytic MCM, albeit at significantly higher computational costs. The effects on the acoustic characteristics were found strongest at lower frequencies and if many cells are in close proximity to each other. Hence, rotational symmetric or square transducers operating at lower frequencies are affected most. The results demonstrate that design approaches based on modeling single cells may lead to significant deviations from design goals. Both, analytic and FE models are suitable tools to estimate the effects of acoustic interactions and to predict the performance. This aids in meeting design requirements of micromachined ultrasound transducers consisting of multiple radiators.