Ultraviolet-B Damages Corneal Endothelium

Cullen, Anthony; Chou, B. Ralph; Hall, M. G.; Jany, S E

doi:10.1097/00006324-198407000-00009

Cited by 59 publications

(39 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may result in decreased corneal sensitivity 9 and damage to the corneal endothelium. 10 Long-term exposure may be partly responsible for conditions such as pterygia, pingueculae, band-shaped keratopathy, and climatic droplet keratopathy. [11][12][13] Repeated exposure to radiant energy on glass blowers, steel workers, blast furnace attendants, and blacksmiths can result in glassblower cataract.…”

Section: Introductionmentioning

confidence: 99%

Ocular disorders in a petroleum industry in Nigeria

Omoti

Waziri-Erameh

Enock

2007

Eye

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Ocular disorders in a petroleum industry in Nigeria

Omoti

Waziri-Erameh

Enock

2007

Eye

View full text Add to dashboard Cite

show abstract

“…Indeed, the effect of UV light has been extensively investigated [1][2][3][4][5][6][7][8]. It has been reported that biotoxic epiphenomena may take place when the threshold level of radiation absorbed in corneal tissues is exceeded, and, consequently, permanent keratocyte damage or loss, epithelium destruction, endothelium edema and necrosis occur, as well as biochemical changes, such as ROS production, protein cross-linking, enzyme inactivation, DNA strand breaks and chemotactic factor release [9][10][11][12][13]. The presence and epiphenomena of ROS, polymorphonuclear cell recruitment, keratocyte loss and development of a diffuse anterior stromal cornea haze are also observed when excimer laser therapy is applied in treating myopia, astigmatism and corneal opacities [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant protection in cultured corneal cells and whole corneas submitted to UV-B exposure

Ciuffi

Pisanello

Pagliai

et al. 2003

Journal of Photochemistry and Photobiology B: Biology

View full text Add to dashboard Cite

Several corneal pathologies are characterized by the presence of reactive oxygen species (ROS); therefore, we evaluated the protection afforded by pirenoxine and melatonin to corneal cell culture and whole rabbit cornea from ultraviolet exposure and other oxidant systems.Rabbit cornea cell (SIRC) plates and whole corneas were exposed to UV-B (80 or 800 mJ/cm 2 ) or incubated with fMLPstimulated autologous macrophages, in the presence or absence of pirenoxine or melatonin (10 À5 M). The protective activity of compounds was assessed by measuring superoxide anion formation, inhibition of oxidation and mitochondrial viability. Moreover the ex vivo protective effect of pirenoxine and melatonin was verified in the whole cornea submitted to UV-B exposure in vitro.Our experimental data demonstrate that pirenoxine and melatonin were able to inhibit the superoxide formation and oxidative effect in cell culture and whole rabbit corneas submitted to UV-B exposure or to incubation with fMLP-stimulated autologous macrophages.Mitochondrial viability was restored in epithelial cells of rabbit cornea but not in SIRCs. Moreover, both compounds are also able to increase ex vivo epithelial corneal cell defences against the in vitro UV-B induced lipid peroxidation.

show abstract

“…Following UV irradiation of the cornea, the latent period depends on the UV dose [22], the UV wavelength [23], and the age of the corneas [24].…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies of UVB irradiation of the cornea describe oxidative damage to the cornea accompanied by stromal swelling [1,22,24] and an increase of corneal light absorption (decrease of corneal light transmission, respec- . The spectrum of untreated corneas (normal corneas) (mean from 12 measurements) without any treatment is also included for comparison.…”

Section: Discussionmentioning

confidence: 99%