Ultraviolet light absorbing pseudophakos

Peyman, Gholam A.; Sloan, Herman D.; Lim, Jin-Ha

doi:10.1016/s0146-2776(82)80030-x

Cited by 19 publications

(7 citation statements)

References 7 publications

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“…It should be mentioned that loading of photoactive organic compounds into polymers has previously been proven to be effective in other commercial applications, such as thin-film polymer displays, 106,107 multi-wavelength photoresists, 108 photostabilization of polymers for sunlight protection, 102,109 and ocular implants. 110…”

Section: Advantages and Limitationsmentioning

confidence: 99%

Optical filtering technologies for integrated fluorescence sensors

2007

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Numerous approaches have been taken to miniaturizing fluorescence sensing, which is a key capability for micro-total-analysis systems. This critical, comprehensive review focuses on the optical hardware required to attenuate excitation light while transmitting fluorescence. It summarizes, evaluates, and compares the various technologies, including filtering approaches such as interference filters and absorption filters and filterless approaches such as multicolor sensors and light-guiding elements. It presents the physical principles behind the different architectures, the state-of-the-art micro-fluorometers and how they were microfabricated, and their performance metrics. Promising technologies that have not yet been integrated are also described. This information will permit the identification of methods that meet particular design requirements, from both performance and integration perspectives, and the recognition of the remaining technological challenges. Finally, a set of performance metrics are proposed for evaluating and reporting spectral discrimination characteristics of integrated devices in order to promote side-by-side comparisons among diverse technologies and, ultimately, to facilitate optimized designs of micro-fluorometers for specific applications.

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Section: Advantages and Limitationsmentioning

confidence: 99%

Optical filtering technologies for integrated fluorescence sensors

2007

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“…22 One primary site of UV damage was at the level of the RPE, with depigmentation in monkeys rendered aphakic or pseudophakic (IOLs without a UV filter). [22][23][24][25] We therefore used pigmented rabbits to evaluate the safety to the retina of the light-delivery system.…”

Section: Discussionmentioning

confidence: 99%

“…One right eye in Group A and 2 right eyes in Group B (groups receiving the higher doses) had retinal lesions after radiation; the lesions were pathologically similar to those described in aphakic monkeys and pseudophakic monkeys with IOLs without an UV filter. [22][23][24][25] In terms of clinical use, the 5.5 mm lock-in beam size, the alignment features and fixation targets of the light-delivery device and the use of a contact lens during treatment and lock-in procedures prevented UV light from bypassing the IOL.…”

Section: Discussionmentioning

confidence: 99%

Retinal safety of the irradiation delivered to light-adjustable intraocular lenses evaluated in a rabbit model

Werner¹,

Chang²,

Haymore³

et al. 2010

Journal of Cataract and Refractive Surgery

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“…17 Aside from unbound MMA monomer from the PMMA IOLs, the UV-absorbing IOLs currently being manufactured contain a variety of organic chromophores that, in sufficient concentration, can exert a cytotoxic effect on the intraocular contents as well as possible photosensitizing effects. 21,22 Most leaching studies are conducted on IOLs after laser damage. 18,23,24 A large percentage of the IOLs currently implanted are posterior chamber lenses.…”

Section: Discussionmentioning

confidence: 99%

Neutral red assay of the cytotoxicity of fluorocarbon-coated polymethylmethacrylate intraocular lenses in vitro

Werner

Legeais

Nagel

et al. 1999

J. Biomed. Mater. Res.

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Polymethylmethacrylate (PMMA) intraocular lenses (IOLs) were coated with Teflon AF, an amorphous, transparent Teflon, to render them highly hydrophobic. Teflon-coated PMMA IOLs were immersed in culture medium for 30 days at 37 degrees C. Four concentrations of the IOL leachables, 2 concentrations of a toxic control (phenol), and complete liquid culture medium (nontoxic control) were incubated for 24 h in a 96-well plate containing confluent L-929 fibroblasts. The cytotoxic effect of each solution on the fibroblasts was quantitatively assessed by measuring the uptake of neutral red by the viable cells. After the extraction of the neutral red using 1% acetic acid-50% ethanol, the optical densities were measured with a microplate reader at 550 nm. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) were used to analyze the surfaces of the IOLs. Only the optical densities in the wells containing fibroblasts that had been in contact with the phenol solutions were significantly lower than those in the wells incubated with the nontoxic control solution (p < 0.01). There were no signs of surface alteration by SEM, apart from some crystals on the IOLs. The crystals were composed of Na and Cl, as demonstrated by XPS. Aqueous extractables from the Teflon-coated IOLs produced no cytotoxic effects in the neutral red assay used.

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Ultraviolet light absorbing pseudophakos

Cited by 19 publications

References 7 publications

Optical filtering technologies for integrated fluorescence sensors

Optical filtering technologies for integrated fluorescence sensors

Retinal safety of the irradiation delivered to light-adjustable intraocular lenses evaluated in a rabbit model

Neutral red assay of the cytotoxicity of fluorocarbon-coated polymethylmethacrylate intraocular lenses in vitro

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