Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples

Delaney, Katherine M; Guillet, Ronnie; Fleming, Robert E.; Yuan, Rong; Pressman, Eva; Vermeylen, Françoise; Nemeth, Elizabeta; O’Brien, Kimberly

doi:10.1093/jn/nxy286

Cited by 19 publications

(18 citation statements)

References 66 publications

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“…The study of Pateva et al [28] demonstrated that children of smoking mothers had significantly lower total iron levels compared with newborns of non-smokers, while Secovanic et al [25] observed increased levels of iron in the cord blood of smokers. In the current study, we observed significantly lower iron levels in children of smoking women; however, it was within the normal range for umbilical cord blood [29,30]. This may be due to the increased iron use for increased erythropoiesis in the blood of children of smoking mothers.…”

Section: Discussioncontrasting

confidence: 43%

Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns

Chełchowska¹,

Maciejewski²,

Mazur³

et al. 2019

IJERPH

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The aim of this study was to assess the influence of active tobacco smoke exposure in utero on the concentration of hepcidin and selected iron markers in umbilical cord blood and to evaluate the relationships between these parameters. Newborns of smoking mothers had significantly lower concentrations of serum hepcidin (p < 0.001), iron, and ferritin (p = 0.043; p = 0.042, respectively), but higher levels of erythropoietin (EPO, p < 0.001) and soluble transferrin receptor (sTfR, p = 0.011) compared with newborns of non-smoking women. Negative correlations between cotinine and the number of cigarettes smoked per day with hepcidin serum level (r = −0.33, p = 0.033, r = −0.32, p = 0.041, respectively) and EPO (r = 0.47, p = 0.002; r = 0.46, p = 0.003, respectively) were found. Univariate analysis defined for the whole group of children revealed significant associations between the concentration of hepcidin and other iron status parameters. In the models estimated separately for smokers and non-smokers, we found relations between the level of hepcidin and erythropoietin (B = −0.23, p = 0.004; B = −0.46, p = 0.01, respectively). In the multivariate regression model, a negative association between hepcidin and EPO concentrations in the whole group of newborns (β = −0.53; p = 0.001) and in the group of smokers (β = −0.57; p = 0.011) was confirmed. The present study shows significant relations between smoking during pregnancy and hepcidin levels in children born at term. Decreased cord serum concentrations of hepcidin associated with high erythropoietin levels suggest induced fetal erythropoiesis, probably due to the hypoxic effects imposed by maternal smoking.

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Section: Discussioncontrasting

confidence: 43%

Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns

Chełchowska¹,

Maciejewski²,

Mazur³

et al. 2019

IJERPH

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“…The current study has raised the need to further investigate the relationship between ferritin and sTfR among infants and young children, and more studies are required to evaluate the association between cord ferritin and sTfR before using TBI estimates to evaluate iron status in the newborns. Delaney et al (9) have also questioned the application of current references ranges for use in neonates and how much they accurately reflect iron status.…”

Section: Discussionmentioning

confidence: 99%

“…The inter-and intra-assay coefficients of variation were all below 5%. Total body iron (TBI) was calculated from the serum transferrin receptor/serum ferritin ratio as follows: TBI (mg/kg) = -[log(R/F ratio) -2.8229]/0.1207 (9).…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…For neonatal populations, studies have suggested thresholds for iron insufficiency (ferritin <76 μg/L) (5) and iron deficiency (<35 μg/L) (6), which have been applied in several previous studies (7,8). But the validity of these markers and thresholds is starting to be questioned (9). Serum soluble transferrin receptor (sTfR) reflects cellular iron needs, and has been combined with serum ferritin levels to assess iron status.…”

Section: Introductionmentioning

confidence: 99%

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Iron stores at birth in a full-term normal birth weight birth cohort with a low level of inflammation

Zhang

Wang

et al. 2020

Bioscience Reports

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Iron stores at birth are essential to meet iron needs during the first 4-6 months of life. This study aimed to investigate iron stores in normal birth weight, healthy, term neonates. Umbilical cord blood samples were collected from apparently normal singleton vaginal deliveries (n=854). Subjects were screened and excluded if C-reactive protein (CRP) >5 mg/L or α1-acid glycoprotein (AGP) >1 g/L, preterm (<37 complete weeks), term <2500g or term >4000g. In total 762 samples were included in the study. Serum ferritin, soluble transferrin receptor (sTfR), hepcidin, and erythropoietin (EPO) were measured in umbilical cord blood samples; total body iron (TBI) (mg/kg) was calculated using sTfR and ferritin concentrations. 19.8% newborns were iron deficient (ferritin <35 μg/L) and an additional 46.6% had insufficient iron stores (ferritin <76 μg/L). There was a positive association between serum ferritin and sTfR, hepcidin and EPO. Gestational age was positively associated with ferritin, sTfR, EPO and hepcidin. In conclusion, we demonstrate a high prevalence of insufficient iron stores in a Chinese birth cohort. The value of cord sTfR and TBI in the assessment of iron status in the newborn is questionable, and reference ranges need to be established.

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“…Therefore, processes of neuronal development, synthesis of neurotransmitters, the myelin and glia cells production are affected. Alterations that occur in neurogenesis, mediated by the de cit of ferritin during embryonic and fetal life will determine permanent consequences on neurocognitive development from birth and throughout life (16) (17). Serum ferritin levels are directly related to iron deposits (18) (19).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Maternal Meat Consumption during Pregnancy and Umbilical Cord Ferritin Concentration

Castro

Camacho

Ceriani

et al. 2020

Preprint

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Background Nutrition during pregnancy impacts the health of the fetus and the newborn, with effects at the epigenetic level determining long-term neurological consequences. Iron requirements in pregnancy are estimated at 27 mg/day. The best absorbed heme iron is found in meat: beef, pork, poultry, and fish. The determination of ferritin in umbilical cord blood can be used to assess iron deposits reached during the fetal stage. Ferritin levels were associated with long-term effects on child development. Methods A descriptive, observational study with prospectively collected data was carried out during one-year period at the Department of Neonatology of the Pereira Rossell Hospital Center (CHPR) in Montevideo, Uruguay. A total of 188 patients met the inclusion criteria. Umbilical cord blood was drawn following a strict cord clamping after one minute of life. Ferritin was measured using the chemoimmunofluorescence method. A maternal nutritional survey was applied, using a qualitative-quantitative form measuring the frequency of consumption of iron source foods and approximated quantities consumed during the last trimester of pregnancy. This survey was focused on maternal consumption of beef as the major heminic iron source in Uruguay. The relationship between these variables was analysed. Results Latent iron deficiency (ferritin in the umbilical cord <100 ng / ml) was associated with less consumption of beef during pregnancy. Fisher p-value: 0.0133, OR: 3.71, 95% CI [1.25 - 11.05]. Conclusions This study considers adequate evidence that low levels of total iron and meat consumption during pregnancy will determine an increased risk of latent iron deficiency and lower levels of ferritin in newborns, and therefore, greater risk of long-term adverse effects on myelination and neurocognitive development.

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Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples

Cited by 19 publications

References 66 publications

Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns

Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns

Iron stores at birth in a full-term normal birth weight birth cohort with a low level of inflammation

Relationship between Maternal Meat Consumption during Pregnancy and Umbilical Cord Ferritin Concentration

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