Recent developments in globalization, education, and technology suggest exciting possibilities for cross-national active teaching and learning in international studies. This paper reviews scholarship on the potential for systematic and intentional cross-national pedagogical innovations in international studies. Three critical themes are identified and explored: culture and cross-national education, collaboration across contexts, and the need for systematic assessment. Each plays an important role in facilitating effective active teaching and learning cross-nationally. A broader examination of the opportunities and challenges of cross-national education in international studies suggests guidelines for a systematic, collaborative cross-national approach to an emerging active teaching and learning research agenda.The scholarship on innovative pedagogical approaches for teaching international studies has expanded significantly in recent decades, becoming more systematic, and offering new exercises with clearly articulated educational goals and procedures (Lantis, Kille, and Krain 2010). However, the majority of published works have tended to focus on discrete exercises for classes in particular settings. Efforts to evaluate the utility of active teaching and learning exercises that cut across different national and cultural contexts have been relatively rare, even though classes often analyze similar phenomena. This gap exists despite developments in globalization, education, and technology that have made cross-national active teaching and learning both increasingly relevant and possible.This review details emerging scholarship on active teaching and learning that addresses the potential for systematic cross-national pedagogical innovations in international studies. We examine apparent reasons behind the growth in a cross-national pedagogical focus and identify and review three key issue areas related to the cross-national teaching of international studies. First, where cross-national engagement has been explored, there are differing conclusions regarding whether culture represents an impediment or an opportunity for cross-national active teaching and learning. Second, the literature identifies constraints originating in different contexts that may limit cross-national