Uncomplicated Malaria

Grobusch, Martin P.; Kremsner, Peter G.

doi:10.1007/3-540-29088-5_4

Cited by 54 publications

(66 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most malaria patients had no specific physical findings and splenomegaly was rarely present at early disease stages (12). Laboratory data showed that thrombocytopenia was the most commonly observed abnormality in our study as previously reported (30)(31)(32). Hyperbilirubinemia, anemia, and elevated transaminase levels were also commonly observed abnormalities.…”

Section: Discussionsupporting

confidence: 80%

“…Hyperbilirubinemia, anemia, and elevated transaminase levels were also commonly observed abnormalities. However, it is difficult to distinguish malaria from nonmalaria febrile illness solely on the basis of physical symptoms and laboratory data (17,32,33). Thus, a prompt diagnosis may be delayed because most patients with malaria have no specific physical and laboratory findings (34).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reducing the Delay in Initiation of Treatment Improved Clinical Outcomes in Patients with Imported Malaria

Nakayama

Shimizu

2014

Jpn J Infect Dis

View full text Add to dashboard Cite

SUMMARY:Although imported malaria poses a grave public health threat in Japan, diagnostic methods and disease management among patients and primary care providers has rarely been reported. Here, we retrospectively reviewed medical records of patients diagnosed with imported malaria in our hospital from 1991 to 2010. Thirty-four malaria cases were identified, corresponding to approximately 2z of the total number of cases in Japan. Falciparum malaria has become predominant in the last 2 decades, and compared with patients in the earlier decade (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000), patients in the latter decade (2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010) showed significantly shorter delays in consulting medical facilities. The overall hospital delay also tended to be shorter in the latter decade, although delayed referral of patients by a week or more was still observed in more than one-third of the cases. The prevalence of risk factors for severe malaria among patients on the day of the referral visit was also lower in the latter decade. Further, the number of WHO-defined cases of severe malaria was smaller, and the length of the hospital stay was not prolonged during that decade. These findings indicated that a shorter delay in seeking medical treatment could reduce the risks of severe malaria.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Reducing the Delay in Initiation of Treatment Improved Clinical Outcomes in Patients with Imported Malaria

Nakayama

Shimizu

2014

Jpn J Infect Dis

View full text Add to dashboard Cite

show abstract

“…A similar observation has been reported from Makueni district, Kenya (Vennervald & Dunne, 2004). Schistosoma mansoni and malaria are major cause of organomegaly in African children Grobusch & Kremsner, 2005). Thus, it is possible therefore that co-infection with Schistosoma and Plasmodium species may have synergistic effects on organ pathology.…”

Section: Discussionsupporting

confidence: 80%

Anaemia and organomegaly associated with parasitic infections among schoolchildren in Sengerema District, north-western Tanzania

Mazigo

Lwambo

Mkoji

et al. 2010

Tanzania J Hlth Res

View full text Add to dashboard Cite

Anaemia and organomegaly are among the health problems affecting schoolchildren in Tanzania and their causes are multifactorial. The objective of this study was to determine the prevalence of anaemia and organomegaly and their relationship with single and multiple parasitic infections among schoolchildren in Sengerema District in north-west Tanzania. This cross sectional study involved 400 schoolchildren. Anaemia and organomegaly were determined using HemoCue photometer and clinical palpation, respectively. A Kato-Katz technique was employed to screen faecal samples for Schistosoma mansoni and other intestinal helminths. Giemsa stained thick and thin blood smears were examined for malaria parasites. The prevalence of anaemia was 19.5% (<11g/dl) and majority of the children had mild (22.8%) to moderate (36.6%) anaemia. Organomegaly (palpable spleen and liver) was detected in 41% of the children and hepatomegaly was the most common (53.7%). The prevalence of S. mansoni, hookworm and P. falciparum were 64.3%, 38% and 13.5% respectively. No significant relationship was observed between single and multiple parasitic infections with anaemia and organomegaly. Logistic regression analysis revealed that increased infections intensity of S. mansoni was significantly associated with an increased likelihood of hookworm concomitant infections (P<0.002). In conclusion, the data confirm that malaria, intestinal schistosomiasis and hookworm are common among school children but are not associated with anaemia and organomegaly. Further longitudinal studies are recommended to establish any such association. The prevalence of parasitic co-infections among schoolchildren calls for an integrated control approach to reduce the burden of these infections. _________________________________________________________________________________

show abstract

“…Adults and older children have a lower prevalence of infection and a lower incidence of clinical symptoms (19), as these individuals acquire immunity from several episodes of malaria during the early part of their lives (20). As a result, an adolescent or adult is more likely to develop uncomplicated or asymptomatic malaria (21). In our present study, we observed that out of 81 P. falciparum-positive cases, only 10 cases were within the Ͻ4-year age group.…”

Section: Discussionsupporting

confidence: 45%

High Prevalence of Asymptomatic Malaria in a Tribal Population in Eastern India

Ganguly

Saha

Guha³

et al. 2013

J Clin Microbiol

View full text Add to dashboard Cite

c Asymptomatic infection by Plasmodium falciparum is an important obstacle to eliminating malaria. Asymptomatic carriers do not seek treatment for infection, and therefore they become a reservoir for the parasite. For this reason, these carriers pose a real public health risk. The systematic identification and treatment of asymptomatic infections should reduce the parasite reservoir. A large reduction in this pool will lower the chance of transmission of the disease. In this study, we screened a tribal population of 1,040 individuals in the Purulia district of West Bengal by using a dual-antigen rapid diagnostic kit (RDK), microscopy, and species-specific PCR. All positive individuals were treated with artemisinin-based combination therapy (ACT) (artesunate plus sulfadoxine-pyrimethamine) and followed for 42 days. Polymorphisms in candidate genes were screened by DNA sequencing. A significant proportion (8.4%) of the study population was infected with P. falciparum but showed no clinical manifestations. The PCR method was more sensitive in detecting infection than the RDK or microscopy. The efficacy of the ACT was 97%. In the pfcrt gene, the mutation K76T (the mutated amino acid is indicated by bold type) was found in 100% of the cases. In the pfmdr1 gene, the mutations N86Y and Y184F were noted in 55.5% and 11% of the cases, respectively. Six different haplotypes were identified in the pfdhfr-pfdhps genes. Most importantly, the quintuple mutant A 16 I 51 R 59 N 108 I 164 -S 436 G 437 E 540 A 581 A 613 was found in 10% of the isolates, which is potentially important for the development of sulfadoxine-pyrimethamine resistance. A significant proportion of the study population harboring P. falciparum does not seek treatment and therefore serves as a reservoir for the parasite, maintaining the natural cycle. If the National Vector Borne Disease Control Programme (NVBDCP) of India is to eliminate malaria, then this hidden parasite burden needs to be addressed properly. Similar study in other parts of the country could help to determine the magnitude of the problem.

show abstract

Uncomplicated Malaria

Cited by 54 publications

References 90 publications

Reducing the Delay in Initiation of Treatment Improved Clinical Outcomes in Patients with Imported Malaria

Reducing the Delay in Initiation of Treatment Improved Clinical Outcomes in Patients with Imported Malaria

Anaemia and organomegaly associated with parasitic infections among schoolchildren in Sengerema District, north-western Tanzania

High Prevalence of Asymptomatic Malaria in a Tribal Population in Eastern India

Contact Info

Product

Resources

About