Increased occurrence of antimicrobial resistance leads
to a huge
burden on patients, the healthcare system, and society worldwide.
Developing antimicrobial materials through doping rare-earth elements
is a new strategy to overcome this challenge. To this end, we design
antibacterial films containing CeO2–x
–TiO2, xanthan gum, poly(acrylic acid), and
hyaluronic acid. CeO2–x
–TiO2 inks are additionally integrated into a hexagonal grid for
prominent transparency. Such design yields not only an antibacterial
efficacy of ∼100% toward Staphylococcus aureus and Escherichia coli but also excellent
antifog performance for 72 h in a 100% humidity atmosphere. Moreover,
FluidFM is employed to understand the interaction in-depth between
bacteria and materials. We further reveal that reactive oxygen species
(ROS) are crucial for the bactericidal activity of E. coli through fluorescent spectroscopic analysis
and SEM imaging. We meanwhile confirm that Ce3+ ions are
involved in the stripping phosphate groups, damaging the cell membrane
of S. aureus. Therefore, the hexagonal
mesh and xanthan-gum cross-linking chains act as a reservoir for ROS
and Ce3+ ions, realizing a long-lasting antibacterial function.
We hence develop an antibacterial and antifog dual-functional material
that has the potential for a broad application in display devices,
medical devices, food packaging, and wearable electronics.