Uncovering the action mechanism of polydatin<i>via</i>network pharmacological target prediction

Pan, Bo; Ren, Yuanyuan; Liu, Liren

doi:10.1039/c8ra03124j

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…However, due to the vast diversity of components in CHM and the complexity of the interaction between those components and the disease, it is still a considerable challenge to uncover the mysteries of CHMs at the molecular level, which to a great extent hampers the general acceptance of TCM worldwide. Recently, a series of computational methods under the umbrella of TCM network pharmacology have been devised, such as the network platform-based prediction of the active compounds from CHMs, which opens up a new path for unraveling the action mechanism of CHM and thereby greatly accelerate the process of CHM-based new drug discovery [13] , [14] , [15] , [16] , [17] .…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor

Pan

Fang

Zhang

et al. 2020

Computational and Structural Biotechnology Journal

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Section: Introductionmentioning

confidence: 99%

Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor

Pan

Fang

Zhang

et al. 2020

Computational and Structural Biotechnology Journal

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“…Polydatin (PD; 3,40,5-trihydroxystibene-3-b-mono-D-glucoside), extracted from Polygonum cuspidatum , is a small natural compound exerting various therapeutic activities including antioxidation and anti-inflammation [ 12 ]. Previous studies have revealed that PD could also ameliorate γ radiation-induced injuries in multiple organs such as the lung, testis, and intestine through scavenging ROS, activating antioxidation cascades, or regulating apoptosis and many other relevant pathways [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Polydatin Attenuates 14.1 MeV Neutron-Induced Injuries via Regulating the Apoptosis and Antioxidative Pathways and Improving the Hematopoiesis of Mice

Guo

et al. 2020

Oxidative Medicine and Cellular Longevity

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With more powerful penetrability and ionizing capability, high energetic neutron radiation (HENR) often poses greater threats than photon radiation, especially on such occasions as nuclear bomb exposure, nuclear accidents, aerospace conduction, and neutron-based radiotherapy. Therefore, there emerges an urgent unmet demand in exploring highly efficient radioprotectants against HENR. In the present study, high-throughput 14.1 MeV neutrons were generated by the high-intensity D-T fusion neutron generator (HINEG) and succeeded in establishing the acute radiation syndrome (ARS) mouse model induced by HENR. A series of preclinical studies, including morphopathological assessment, flow cytometry, peripheral complete blood, and bone marrow karyocyte counting, were applied showing much more serious detriments of HENR than the photon radiation. In specific, it was indicated that surviving fraction of polydatin- (PD-) treated mice could appreciably increase to up to 100% when they were exposed to HENR. Moreover, polydatin contributed much in alleviating the HENR-induced mouse body weight loss, spleen and testis indexes decrease, and the microstructure alterations of both the spleen and the bone marrow. Furthermore, we found that the HENR-damaged hematopoiesis was greatly prevented by PD treatment in such aspects as bone marrow hemocytogenesis, splenocytes balancing, or even the peripheral blood cellularity. The additional IHC investigations revealed that PD could exert potent hematopoiesis-promoting effects against HENR via suppressing apoptosis and promoting the antioxidative enzymes such as HO-1.

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“…The cellular mechanisms of polydatin in various tissues and organs have been thoroughly reviewed by Du et al (2013) [ 9 ]. The potential protein targets of polydatin have also been identified [ 10 ]. It is supposed that polydatin can cross the BBB as it protects brain damage from cerebral ischemia when administered intravenously [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Polydatin Against Dementia-Related Disorders

Tang

2020

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: Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and therefore, finding an effective treatment is of the utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, it’s glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia-related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.

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Uncovering the action mechanism of polydatinvianetwork pharmacological target prediction

Abstract: Polydatin (PD), a small natural compound originally extracted fromPolygonum cuspidatum, exerts distinct biological functions in a variety of diseases.

Cited by 10 publications

References 44 publications

Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor

Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor

Polydatin Attenuates 14.1 MeV Neutron-Induced Injuries via Regulating the Apoptosis and Antioxidative Pathways and Improving the Hematopoiesis of Mice

Protective Effects of Polydatin Against Dementia-Related Disorders

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