It is increasingly recognized that water scarcity, rather than a lack of arable land, will be the major constraint to increase agricultural production over the next few decades. Therefore, water represents a unique agricultural asset to drive agricultural sustainability. However, its planning, management and usage are often influenced by a mix of interdependent economic, engineering, social, hydrologic, environmental, and even political factors. Such a complex interdependency suggests that a sociotechnical approach to water resources management, a subject of the field of Hydroinformatics, represents a viable path forward to achieve sustainable agriculture. Thus, this paper presents an overview of the intersection between hydroinformatics and agriculture to introduce a new research field called agricultural hydroinformatics. In addition, it proposes a general conceptual framework taking into account the distinctive features associated with the sociotechnical dimension of hydroinformatics when applied in agriculture. The framework is designed to serve as a stepping-stone to achieve, not only integrated water resources management, but also agricultural sustainability transitions in general. Using examples from agricultural water development to horticultural and livestock farming, the paper highlights facets of the framework applicability as a new paradigm on data flows/sources consideration, and information and simulation models engineering as well as integration for a holistic approach to water resources management in agriculture. Finally, it discusses opportunities and challenges associated with the implementation of agricultural hydroinformatics and the development of new research areas needed to achieve the full potential of this emerging framework. These areas include, for example, sensor deployment and development, signal processing, information modeling and storage, artificial intelligence, and new kind of simulation model development approaches.