Understanding controlled drug release from mesoporous silicates: Theory and experiment

Ukmar, Tina; Maver, Uroš; Planinšek, Odon; Kaučič, Venceslav; Gaberšček, Miran; Godec, Aljaž

doi:10.1016/j.jconrel.2011.06.038

Cited by 92 publications

(62 citation statements)

References 24 publications

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“…This could be due to the described above fact that both of silica types exhibit different morphology structures. The differences in physicochemical properties such the surface area and porosity determine the drug release mechanism via influence the accessibility and mobility of drug molecules inside the pores of silica material and then their release behaviour [71,92].…”

Section: In Vitro Release and Kinetic Studiesmentioning

confidence: 99%

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

AbouAitah¹,

Aa²,

Świderska-Środa³

et al. 2016

J Nanomed Nanotechnol

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Section: In Vitro Release and Kinetic Studiesmentioning

confidence: 99%

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

AbouAitah¹,

Aa²,

Świderska-Środa³

et al. 2016

J Nanomed Nanotechnol

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“…Although many authors claimed to synthesize nanoparticles, only those showing proof of nanosized diameters [13,[15][16][17][18][19][20][21] are labeled as MSN (if no proof of crystal structure is shown by XRD). While some MCM-41 materials are listed [12,[22][23][24], only one was found for SBA-15 particles [24] in the submicron range, although resembling more an hexagonal shape, as it will be discussed later. Hiroshima Mesoporous Materials (HMM) [25] are another alternative where the polymerization of styrene is carried inside the surfactant micelles, and the hydrolyzed silica simultaneously condensates on the growing polystyrene chains inside the drops.…”

Section: Sizes and Morphologiesmentioning

confidence: 99%

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Beltrán-Osuna

Perilla

2015

J Sol-Gel Sci Technol

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Continuous research in prominent fields such as biotechnology, biomedicine and nanopharmaceutics has brought the development of a widespread class of materials, and studies for mesoporous materials have been exponentially growing lately. The purpose of this review is to provide a useful guide for different materials, methods and configurations that have been reported in the last 5 years for the synthesis of spherical mesoporous silica particles (MSP), in the colloidal size range (1-1000 nm). MSP exhibit several limitations that must be overcome in order to enable their medical and clinical use. Surface modification of these particles will allow getting new promising characteristics of these materials, including better drug release control and biocompatibility improvement. These modified MSP could be potentially used in many biomedical applications, especially for drug delivery systems. Emphasis is made on the pore size, diameter and shape of the final particles since these parameters will establish key characteristics, i.e., drug delivery profile, loading capacity and efficiency. Graphical Abstract Spreading the use of mesoporous silica particles in biomedicine is possible by the improvement of its inner characteristics through surface modification. This may be done by chemical functionalization or by coating with macromolecular layers or brushes, thus creating novel responsive core-shell hybrid composites to be used as carriers for drug delivery applications.

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“…5 c). Since 1st deviations from the obtained release data and taking into account the error bars revealed at least two different regions (judging by the always present break in the release curve at 20 min regardless of the sample, it could well be three coupled mechanisms) in the release profile (the regions are separated with a blue dashed line, showing possible three regions of different release mechanism), commonly used models to explain the drug release (Ukmar et al 2011(Ukmar et al , 2012 could not be applied for additional data evaluation.…”

Section: Release Of Dcf From the Filmsmentioning

confidence: 99%

Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials

Maver

Mostegel

et al. 2014

Cellulose

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In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DS Si :2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV-Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.

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Understanding controlled drug release from mesoporous silicates: Theory and experiment

Cited by 92 publications

References 24 publications

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials

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