We report direct experimental evidence of interspecies ion separation in direct-drive, inertial-confinement-fusion experiments on the OMEGA laser facility. These experiments, which used plastic capsules with D2/Ar gas fill (1% Ar by atom), were designed specifically to reveal interspecies ion separation by exploiting the predicted, strong ion thermo-diffusion between ion species of large mass and charge difference. Via detailed analyses of imaging x-ray-spectroscopy data, we extract Ar-atom-fraction radial profiles at different times, and observe both enhancement and depletion compared to the initial 1%-Ar gas fill. The experimental results are interpreted with radiation-hydrodynamic simulations that include recently implemented, first-principles models of interspecies ion diffusion. The experimentally inferred Ar-atom-fraction profiles agree reasonably, but not exactly, with calculated profiles associated with the incoming and rebounding first shock. * * * We acknowledge R. Aragonez, T. Archuleta, J. Cobble, J. Fooks, V. Glebov, M. Schoff, T. Sedillo, C. Sorce, R. Staerker, N. Whiting, B. Yaakobi, and the OMEGA operations team for their support in experimental planning, execution, and providing processed x-ray and neutron data.