Understanding the Link Between Gut Microbiome and Urinary Stone Disease

Lee, Justin A.; Stern, Joshua M.

doi:10.1007/s11934-019-0882-8

Cited by 17 publications

(8 citation statements)

References 57 publications

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“…In general, the composition of intestinal microbiota changes according to age, diet and drug use, and differs across ethnicities and geographic regions (2,3,5,8,17). Loss of Oxalobacter formigeneses is hypothesized to be a factor that produces COKS, as Oxalobacter formigeneses metabolizes oxalate in the intestine; however, several studies, including the present, question the validity of this hypothesis (2,38). The mechanism underlying the formation of calculi has yet to be fully elucidated.…”

Section: Discussionmentioning

confidence: 85%

Intestinal dysbacteriosis leads to kidney stone disease

et al. 2020

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Section: Discussionmentioning

confidence: 85%

Intestinal dysbacteriosis leads to kidney stone disease

et al. 2020

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“…To date, more studies on the relationship between gut microbiota and nephrolithiasis are reported ( Tang et al, 2018 ). They found that the cause of calcium oxalate stone was related to a group of bacteria involved in oxalate degradation and transportation, rather than a single kind of bacteria ( Lee and Stern, 2019 ). The relationship of gut microbiota and calcium oxalate stone has been investigated in a limited amount ( Stern et al, 2016 ; Lee and Stern, 2019 ), especially with no study of gut microbiota and UAS, to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone

et al. 2022

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Previous studies suggest that patients with nephrolithiasis exhibit dysbiosis in their gut microbiota, but those studies were conducted in calcium oxalate stone patients. We aimed to explore the association of gut microbiota and biochemical features of renal uric acid stone (UAS) patients in a Chinese population and identify the related bacteria that may affect the pathopoiesis of UAS. A case-control study of 117 patients with UAS, 123 patients with gout, and 135 healthy controls were included from January 2014 to October 2020. For each subject, data on demographics, biochemical parameters of blood and urine were analyzed. Fifteen patients with gout, 16 patients with UAS, 17 UAS patients with gout, and 17 healthy subjects were enrolled and provided fecal samples. The characteristics of gut microbiota were explored by using 16S ribosomal RNA (rRNA) gene sequencing and analyzed by using a combination of software mother and R. Hyperuricemia was the main risk factor for the development of gout and UAS. Obesity, dyslipidemia, and aciduria were unique risk factors for UAS patients. The richness, diversity, and relative abundance of dominant bacteria at the phylum and genus levels of gut microbiota in UAS patients were significantly distinct from other subjects. Abundance of Bacteroides and Fusobacterium was significantly positively correlated with the serum uric acid (UA) level of UAS patients. Fusobacteria was involved in the metabolism and degradation of certain short-chain fatty acids, amino acids, and sugars in pathopoiesis of UAS, and inhibited their synthesis pathways. Fusobacteria may be related to the pathogenesis of UAS, and this finding contributes to the personalized treatment of UAS from the perspective of maintaining micro-ecological equilibrium in gut.

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“…High-throughput sequencing has shown that nephrolithiasis involves the Enterobacteriaceae genus in the urinary microbiome, including E. coli species [39]. Barr-Beare et al [40] reported associations between E. coli and renal CaOx deposits.…”

Section: ) Escherichia Colimentioning

confidence: 99%

Impact of the Human Microbiome on Nephrolithiasis

Jung

Lee

2021

Urogenit Tract Infect

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Nephrolithiasis has many causes, and its prevalence is increasing worldwide. The interest in the human microbiome is growing because of the advance of new diagnostic techniques, and recent studies have suggested a link between the microbiome and nephrolithiasis. This paper reviewed the role of the microbiome in nephrolithiasis. The absence of Oxalobacter formigenes induces hyperoxaluria, which promotes calcium oxalate stone (CaOx) formation. Escherichia coli promote CaOx supersaturation through hypocitraturia caused by the bacterial production of citrate lyase. Infection stones are associated with urea-splitting organisms, particularly Proteus mirabilis, and the stones themselves contain many species of bacteria.

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Understanding the Link Between Gut Microbiome and Urinary Stone Disease

Cited by 17 publications

References 57 publications

Intestinal dysbacteriosis leads to kidney stone disease

Intestinal dysbacteriosis leads to kidney stone disease

Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone

Impact of the Human Microbiome on Nephrolithiasis

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