Underweight and Weight Change Increases End-Stage Renal Disease Risk in Patients with Diabetes: A Nationwide Population-Based Cohort Study

Bae, Eun Hui; Oh, Tae Ryom; Suh, Sang Heon; Yang, Eun Mi; Choi, Hong Sang; Kim, Chang Seong; Kwon, Seong; Kim, Tae Hyuk; Han, Kyungdo; Kim, Soo Wan

doi:10.3390/nu14010154

Cited by 8 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, the participants with MetS were associated with a high baseline eGFR after multivariable analysis. In contrast, previous studies on patients with and without CKD have reported that those with MetS had a lower eGFR at baseline than those without MetS [29][30][31][32]. A possible explanation for this discrepancy may be due to glomerular hyperfiltration.…”

Section: Discussionmentioning

confidence: 66%

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

Chen²,

Wu³

et al. 2022

Biomedicines

View full text Add to dashboard Cite

A rapid decline in renal function can cause many complications, and therefore it is important to detect associated risk factors. Few studies have evaluated the associations among obesity-related indices and metabolic syndrome (MetS) with renal function decline. This longitudinal study aimed to explore these relationships in a large cohort of Taiwanese participants. The studied obesity-related indices were waist-to-height ratio (WHtR), A body shape index (ABSI), visceral adiposity index (VAI), lipid accumulation product (LAP), waist-to-hip ratio (WHR), body roundness index (BRI), conicity index (CI), body mass index (BMI), body adiposity index (BAI) and abdominal volume index (AVI). We included 122,068 participants in the baseline study, of whom 27,033 were followed for a median of four years. The baseline prevalence of MetS was 17.7%. Multivariable analysis showed that the participants with MetS and high VAI, WHtR, WHR, LAP, CI, BRI, BMI, BAI, AVI, and ABSI values were significantly associated with a high baseline estimated glomerular filtration rate (eGFR) (all p < 0.001). In addition, the participants with MetS (p < 0.001), high WHtR (p = 0.007), low LAP (p < 0.001), high BRI (p = 0.002), high CI (p = 0.002), high AVI (p = 0.001), high VAI (p = 0.017), and high ABSI (p = 0.013) were significantly associated with a low △eGFR, indicating a rapid decline in renal function. These results showed associations between MetS and high values of obesity-related indices except LAP with high baseline eGFR and rapid decline in kidney function. These findings suggest that screening for MetS and obesity may help to slow the decline in renal function in high-risk populations.

show abstract

Section: Discussionmentioning

confidence: 66%

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

Chen²,

Wu³

et al. 2022

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Furthermore, in patients with DM, a weight loss of more than 10% was linked to the quickest decline in renal function. As a result, patients with diabetes must lose at least 5% of their body weight to avoid the development of ESRD (Bae et al 2022). The results listed in Table (2) illustrate that microalbumin in the urine of DM showed no significant difference as compared to the C group (P>0.05) while a highly significant increase (P<0.001) was found between DN and C group.…”

Section: Resultsmentioning

confidence: 99%

impact of oxidative stress on the activity of adenosine deaminase and its isoenzymes in nephropathy patients from Wasit-Iraq

Ahmed¹,

Qaddoori²,

Majeed³

et al. 2022

ijhs

View full text Add to dashboard Cite

Diabetes mellitus is a group of metabolic disorders that share with symptoms of hyperglycemia led to elevated free radical activity. Hyperglycemia is linked to a higher level of (ADA), which is one of the factors that cause oxidative stress by creating reactive oxygen species (ROS), that leads to insulin resistance. This study aimed to determine the relationship between serum total adenosine deaminase(TADA) and its isoenzyme (ADA1and ADA2) with the progression of nephropathy in patients with type 2 diabetes using a case-control study from Wasit-Iraq. In addition, we aimed to find if there is a link between oxidative stress with TADA and its isoenzyme. The One-way ANOVA was used to compare the mean values of fasting plasma sugar (FPS), total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde (MDA), microalbumin in urine, HbA1c, and TADA, ADA1, ADA2 between the three studied groups (Control(C), diabetic patients(DM), and diabetic nephropathy patient(DN). The results of our study revealed that there was a highly significant increase in TADA and its isoenzyme activities of DM and DN groups, as compared to the C group.

show abstract

“…Interestingly, we found that underweight patients were independently associated with DKD; the adjusted odds ratio was even higher than that for obesity. A Korean nationwide cohort study reported that the underweight BMI category was an independent risk factor for ESKD among patients with diabetes 35 . Moreover, those with weight loss > 10% had the fastest decline in kidney function 35 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of diabetic kidney disease and the associated factors among patients with type 2 diabetes in a multi-ethnic Asian country

Wan,

Hairi,

Mustapha

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The actual prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D) in Malaysia is unknown. We aimed to determine the prevalence of DKD and its associated risk factors among T2D patients in Malaysia. An analytical cross-sectional study was conducted using the year 2022 clinical audit dataset from the National Diabetes Registry. DKD was defined as albuminuria, a decreased glomerular filtration rate, or both. Among 80,360 patients, 62.2% were female, 68.4% were Malay, and the mean age was 61.4 years. A total of 56.7% (95% CI 56.4–57.1%) of patients were found to have DKD. Increasing age, male sex, Malay ethnicity, longer duration of diabetes, overweight, obesity, hypertension, diabetic retinopathy, diabetic foot ulcer, nontraumatic lower-extremity amputation, ischaemic heart disease, stroke, insulin, higher numbers of antihypertensive agents, antiplatelet agents, poorer HbA1c control, higher systolic blood pressure, non-achievement of triglyceride target, and non-attainment of HDL-cholesterol goal were independent risk factors associated with DKD. Clinicians, program managers, and health policymakers should target modifiable factors to manage DKD and prevent its progression to end-stage kidney disease in Malaysia.

show abstract

Underweight and Weight Change Increases End-Stage Renal Disease Risk in Patients with Diabetes: A Nationwide Population-Based Cohort Study

Cited by 8 publications

References 33 publications

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

impact of oxidative stress on the activity of adenosine deaminase and its isoenzymes in nephropathy patients from Wasit-Iraq

Prevalence of diabetic kidney disease and the associated factors among patients with type 2 diabetes in a multi-ethnic Asian country

Contact Info

Product

Resources

About