Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review

Hiroshima, Kenzo; Wakahara, Takashi; Akimoto, Harutoshi; Yanagië, Hironobu; Harigaya, Kenichi; Yasuhara, Hiroshi

doi:10.3892/mco.2016.1046

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…12 The eventual unsatisfactory outcome suggests that this tumor's aggressive activity is consistent with that observed in previously documented cases. 13,14 This shows that comprehensive adjuvant therapy should be researched to increase survival in individuals with advanced undifferentiated gallbladder cancer, because surgery alone may not be sufficient. For SWI/SNF-deficient malignancies, the EZH2 inhibitor tazemetostat has become a popular targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

Primary Undifferentiated Gallbladder Carcinoma With SMARCA4 Deletion: A Case Report and Review of the Literature

Xiaoxu,

Xianghong

2023

Int J Surg Pathol

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Background. Undifferentiated gallbladder carcinoma is a rare type of cancer with poor prognosis, due to the absence of specific clinical manifestations, and the final diagnosis depends on pathological and immunohistochemical examinations. However, only a few reports of SMARCA4-deficient undifferentiated gallbladder tumor have been published to date. Therefore, we report the diagnosis and treatment of an undifferentiated gallbladder carcinoma with SMARCA4 deficiency. Case Presentation. A 65-year-old woman with undifferentiated gallbladder carcinoma was treated using traditional Chinese medicine and underwent palliative surgery in our hospital. The postoperative pathology showed SMARCA4-deficient undifferentiated gallbladder carcinoma with metastasis to the abdominal lymph nodes. Conclusions. This case report contributes to the limited literature regarding undifferentiated carcinoma without SMARCA4 in the gallbladder.

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Section: Discussionmentioning

confidence: 99%

Primary Undifferentiated Gallbladder Carcinoma With SMARCA4 Deletion: A Case Report and Review of the Literature

Xiaoxu,

Xianghong

2023

Int J Surg Pathol

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“…Carcinosarcoma of the gallbladder is called “undifferentiated carcinoma”, “sarcomatoid carcinoma,” or “spindle-cell carcinoma.” Thus, the terminology has not yet been unified( 13 ). The pathogenesis of gallbladder carcinosarcoma remains poorly known.…”

Section: Discussionmentioning

confidence: 99%

Case Report: A Case of Gallbladder Carcinosarcoma With Osteoclast-like Multinucleated Giant Cells that Was Associated With RANK‐RANKL Signaling

Niwa¹,

Tomita²,

Watanabe³

et al. 2022

Pathol. Oncol. Res.

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Introduction: Gallbladder carcinosarcoma with osteoclast-like multinucleated giant cells is known to be most uncommon form of gallbladder cancer. Owing to its rarity, the pathogenesis of gallbladder carcinosarcoma with osteoclast-like multinucleated giant cells is largely unknown.Case Presentation: We present a case of carcinosarcoma with osteoclast-like multinucleated giant cells in the gallbladder. A 57-year-old woman visited our hospital due to jaundice. An examination revealed calculous cholecystitis and gallbladder carcinoma. After cholecystectomy, macroscopic examination disclosed one whitish mass and another distinct brown and pendulous mass in the body of the gallbladder. A pathological examination revealed that each mass had a different histological type: adenosquamous carcinoma and carcinosarcoma with osteoclast-like multinucleated giant cells. Immunohistochemistry revealed that these osteoclast-like multinucleated giant cells are CD68(+), CD163(−), and MIB-1(−). In addition, the osteoclast-like multinucleated giant cells showed the strong expression of RANK and sarcoma cells around the osteoclast-like multinucleated giant cells, were positive for RANKL. Furthermore, RUNX2 was positive for some sarcoma cells. The result indicated that osteoclastic and osteoblast-like differentiation occurred in our case.Conclusion: To our knowledge, this is the first case to show the interaction of RANK-RANKL signaling in gallbladder carcinosarcoma with osteoclast-like multinucleated giant cells.

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“…If, however, a tumor is “solitary type”, surgical resection might lead to a good prognosis, as in the present case. However, in general, undifferentiated carcinoma of the digestive system seems to have a poor prognosis [ [7] , [8] , [9] , [10] ]. Therefore, multimodal therapy should also be considered.…”

Section: Discussionmentioning

confidence: 99%

A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review

Hiraki

Kono

Miyoshi

et al. 2018

International Journal of Surgery Case Reports

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HighlightsUndifferentiated carcinoma of the liver is extremely rare disease.We experienced a long-term survivor of undifferentiated carcinoma of the liver successfully treated with radical hepatectomy.The tumor showed a huge hypovascular cystic mass with ring enhancement and partial solid component.It might grow quickly and show necrosis at the center of the tumor, making it difficult to distinguish from liver abscess.This disease has markedly different clinical and biological features from common primary malignant tumor of the liver.

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Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review

Cited by 8 publications

References 16 publications

Primary Undifferentiated Gallbladder Carcinoma With SMARCA4 Deletion: A Case Report and Review of the Literature

Primary Undifferentiated Gallbladder Carcinoma With SMARCA4 Deletion: A Case Report and Review of the Literature

Case Report: A Case of Gallbladder Carcinosarcoma With Osteoclast-like Multinucleated Giant Cells that Was Associated With RANK‐RANKL Signaling

A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review

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