Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: Report of a case with osteochondroid differentiation

Manduch, Marosh; Dexter, David F.; Jalink, Diederick; Vanner, Stephen; Hurlbut, David

doi:10.1016/j.prp.2008.11.006

Cited by 32 publications

(28 citation statements)

References 12 publications

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“…Histologically, the tumor combines two main cell populations, a malignant mononuclear cells population and the scattered nonneoplastic osteoclast-like giant cells [ 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Undifferentiated Pancreatic Carcinoma with Osteoclast-Like Giant Cells: a Case Report

Njoumi

Elalami

Attolou

et al. 2014

J Gastrointest Canc

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“…Histologically, the tumor combines two main cell populations, a malignant mononuclear cells population and the scattered nonneoplastic osteoclast-like giant cells [ 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Undifferentiated Pancreatic Carcinoma with Osteoclast-Like Giant Cells: a Case Report

Njoumi

Elalami

Attolou

et al. 2014

J Gastrointest Canc

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“…Macrophages express CD68, a glycoprotein that binds to low density lipoprotein 9,24 . As well as monocytes/macrophages, giant cells express the CD68 surface receptor 12 . Polarized macrophages are referred to as M1 or M2 16 .…”

mentioning

confidence: 99%

Histomorphometric analysis of the phenotypical differentiation of recruited macrophages following subcutaneous implantation of an allogenous acellular dermal matrix

Mueller

Schultze‐Mosgau

2011

International Journal of Oral and Maxillofacial Surgery

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“…Increase in paw volume (%) phages, CD68 was also expressed on monocytes and giant cells [31] and 2) CCR7 can be found on mature dendritic cells as well as T-and NK-cells [32]. Studies in fetal wound healing showed that skin wounds on a mammalian fetus healed rapidly and without scar formation [33].…”

Section: Methodsmentioning

confidence: 99%

Rosehip Oil Promotes Excisional Wound Healing by Accelerating the Phenotypic Transition of Macrophages

et al. 2018

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Poor wound healing is a major and global threat to public health. Efforts have been made to better understand the underlying mechanisms and develop effective remedies, though the advancements that have been made are still limited. As there are no effective and generally applicable therapies available for skin injuries and fibrosis, it is urgent to develop new drugs and therapies that facilitate wound healing and effectively improve scars. In this study, GC-MS analysis was performed to identify the chemical composition of rosehip oil. The excisional wound healing model and the carrageenan-induced paw edema method were respectively applied to evaluate the wound healing activity and anti-inflammatory activity of rosehip oil. Hematoxylin and eosin staining was used to assess the pathological changes of sections, and Sirius-red staining was performed to analyze the ratio of collagen I/III in wound tissues. Immunohistological staining for CD68, CCR7 (CD197), CD163, TGF-1, and -SMA was applied to determine the macrophage phenotypes transition (M1-to-M2) and demonstrate the scar-improving efficacy of rosehip oil on wound healing. Results showed that rosehip oil significantly promoted wound healing and effectively improved scars. This efficacy might be exerted by accelerating the macrophage phenotypes transition and inhibiting the process of epithelial-mesenchymal transition.

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Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: Report of a case with osteochondroid differentiation

Cited by 32 publications

References 12 publications

Undifferentiated Pancreatic Carcinoma with Osteoclast-Like Giant Cells: a Case Report

Undifferentiated Pancreatic Carcinoma with Osteoclast-Like Giant Cells: a Case Report

Histomorphometric analysis of the phenotypical differentiation of recruited macrophages following subcutaneous implantation of an allogenous acellular dermal matrix

Rosehip Oil Promotes Excisional Wound Healing by Accelerating the Phenotypic Transition of Macrophages

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