Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy

Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

“…According to the MTT results, MSNs without EPI showed negligible cytotoxicity because of their biocompatibility and low concentration of MSNs which was used for drug delivery (under 40 µg /mL) and it consistent with former studies (Data not shown) [40,55]. The results of MTT were compatible with the in vitro EPI release and the flow cytometry analysis.…”

Adsorption of antitumor antibiotic doxorubicin on MCM-41-type silica surface

“…In order to minimize undesired damages of healthy cells without reducing therapeutic action of Dox, drug carrier systems are widely used (Aznar et al, 2011;Bernardos et al, 2010;Chen et al, 2013;Gao et al, 2011;Gu et al, 2012;Hu et al, 2013;Knezevic et al, 2011Knezevic et al, , 2013Lee et al, 2010Lee et al, , 2011Maeda et al, 2003;Meng et al, 2010;Mishra et al, 2014;Nishiyama and Kataoka, 2003;Prokopowicz and Przyjazny, 2007;Prokopowicz et al, 2016;Safari and Zarnegar, 2014;Singh et al, 2011;Tan et al, 2011;Wang et al, 2011;Yang et al, 2008;Yokoyama, 2011;Yuan et al, 2011;Zhang et al, 2011). Among them, ordered mesoporous silicas of MCM-41 type are the most promising solid supports for the formation of biologically active systems (Aznar et al, 2011;Bernardos et al, 2010;Gu et al, 2012;Hu et al, 2013;Knezevic et al, 2011Knezevic et al, , 2013Lee et al, 2010Lee et al, , 2011Meng et al, 2010;Prokopowicz et al, 2016;Yuan et al, 2011).…”

Facile fabrication of hollow mesoporous Eu 3+ -doped Gd 2 O 3 nanoparticles for dual-modal imaging and drug delivery

“…At pH 7.4 (curve b), approximately 35 % of the DOX was released within 5 h and it remained unchanged during about 10 h. While at pH 5.3 (curve a), a more acidic internal microenvironment in cancer cells, 82 % of the loaded DOX was released in the same time. This trend isattributed to the increased hydrophilicity and higher solubility of DOX in lower pH caused by increased protonated -NH 2 groups on DOX[46]. These results imply that the Eu 3+ -doped Gd 2 O 3 HMNPs drug delivery system has a strongly pH-dependent drug release of DOX.…”