Unilateral Ovariectomy Increases Loss of Primordial Follicles and is Associated with Increased Metestrous Concentration of Follicle-Stimulating Hormone in Old Rats1

Meredith, S.; Dudenhoeffer, G.; Butcher, R. L.; Lerner, S. P.; Walls, Tony

doi:10.1095/biolreprod47.2.162

Cited by 36 publications

(13 citation statements)

References 24 publications

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“…In support of this, we have found that while the expression of BMPRIB was detectable in follicular cells of mouse primordial follicles, FSHR was absent but later appeared in primary follicles. These data together with a previous report in rat (Moore & Shimasaki 2005) contradict previous reports (Meredith et al 1992, Flaws et al 1997 and therefore suggest the presence of a complex interplay between gonadotrophins and other growth factors such as BMPs where direct and indirect cross-signalling regulates ovarian function (Tanwar & McFarlane 2011). The reported decrease in primordial follicles after eCG treatment (Tanwar et al 2008) conflicts with the present result probably due to the manual counting method used in the previous study instead of the automated stereology used in this work.…”

Section: The Role Of Bmps In Ovarian Functioncontrasting

confidence: 96%

“…Specifically, it has been commonly believed that FSH may be involved in the initial recruitment of primordial follicles (Meredith et al 1992, Flaws et al 1997. However, recent observations have demonstrated that these follicles develop normally in mice lacking active FSH or FSH receptor (FSHR) due to gene mutation in FSH b subunit (Siegel et al 2013) or FSHR (Dierich et al 1998), suggesting that initial follicle recruitment is gonadotrophin independent (Orisaka et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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The impact of passive immunisation against BMPRIB and BMP4 on follicle development and ovulation in mice

Al-Samerria¹,

Al-Ali²,

McFarlane³

et al. 2015

Reproduction

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The primordial follicle reserve is the corner stone of female fertility and determines the longevity and quality of reproduction. Complete depletion of this reserve will lead to primary infertility, and the key-limiting step of follicle depletion is the transition from primordial to primary follicles. It has been reported that this process is gonadotrophin-independent, but other conflicting reports are indicated otherwise and this discrepancy needs to be unequivocally clarified. The aim of this study was to investigate the role of bone morphogenetic proteins (BMPs) in the regulation of folliculogenesis in mice passively immunised against BMP receptor 1B (BMPRIB) and BMP4. While a stereological study revealed that the numbers of primordial follicles in immunised mice were significantly higher when compared with control animals, treatment with equine chorionic gonadotrophin showed no effect. In parallel, immunofluorescence microscopy revealed the presence of BMPRIB but not FSH receptor in primordial follicles. The number of primary follicles in immunised mice were also significantly increased when compared with control animals. After puberty, the rates of depletion of primordial and primary follicles were increased with age, particularly in treated animals; however, there was no significant difference between the treatment groups of the same age. Based on these results together with our previous reports in sheep and mice, we confirm that the attenuation of BMP signalling system can be an effective approach to sustain the primordial follicle reserve while promoting the development of growing follicles, ovulation and consequently overall female fertility.

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Section: The Role Of Bmps In Ovarian Functioncontrasting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

The impact of passive immunisation against BMPRIB and BMP4 on follicle development and ovulation in mice

Al-Samerria¹,

Al-Ali²,

McFarlane³

et al. 2015

Reproduction

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“…There is very little evidence to suggest that unilateral oophorectomy by itself has any major impact on the natural age related decline in fertility and on the time of menopause. Women with a single ovary may have slightly elevated serum FSH concentrations (Cooper and Thorp, 1999) and animal studies have shown increased serum FSH concentrations and numbers of antral follicles in the remaining ovary but decreased total number of antral follicles per animal, compensatory hypertrophy in the remaining ovary and menstrual irregularity after unilateral oophorectomy (Butcher, 1985;Martin et al, 1986;Meredith et al, 1992). However, women with one ovary appear to have an unreduced fertility potential, be it naturally or via IVF (Lass, 1999).…”

Section: Discussionmentioning

confidence: 99%

Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique

Rosendahl

Schmidt

Ernst

et al. 2011

Reproductive BioMedicine Online

176

126

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This paper presents the Danish 10-year experience (1999-2009) with cryopreservation (n=386) and autotransplantation of ovarian tissue (n=18). Before applying the technique to humans, the method was thoroughly tested and validated. The cryoprotectant solution was chosen after histological evaluation of mouse and human ovarian tissue after freezing with four different combinations of cryoprotectants. Viability was confirmed by transplantation of frozen-thawed human ovarian tissue (n=49) to oophorectomized Nude mice. Viability after transport of fresh tissue 4-5h prior to freezing had previously been validated. Overnight transport of fresh ovarian tissue prior to cryopreservation was evaluated when human ovarian tissue was kept on ice for 20h and then cryopreserved. The thawed ovarian tissue was transplanted to an oophorectomized Nude mouse and histology confirmed viability. In Denmark 12 women have received a total of 18 autotransplantations of ovarian tissue. All women resumed ovarian function and three healthy babies were born to two women. In both women, the tissue was transported on ice for 4-5h prior to cryopreservation. Ovarian tissue cryopreservation is an important method for fertility preservation; however, before applying the method clinically, each laboratory should perform thorough validation of their technique.

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“…Furthermore, unilateral oophorectomy increases the loss of remaining primordial follicles in middle-aged rats but not in young rats operated on at 30 days of age (158). Likewise, treatment with a chemotherapy agent, busulfan, decreases the resting follicle pool by more than 90% in rats and substantially accelerates follicle depletion (159).…”

Section: B Do Women Of Reproductive Age Who Have Undergone Unilateramentioning

confidence: 96%

Initial and Cyclic Recruitment of Ovarian Follicles*

2000

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Mammalian ovaries consist of follicles as basic functional units. The total number of ovarian follicles is determined early in life, and the depletion of this pool leads to reproductive senescence. Each follicle develops to either ovulate or, more likely, to undergo degeneration. The dynamics of ovarian follicle development have interested endocrinologists and developmental biologists for many years. With the advent of assisted reproductive techniques in humans, the possibility of regulating follicle development in vivo and in vitro has gained clinical relevance. In this review, we focus upon key branching points during the development of ovarian follicles as well as factors involved in determining the eventual destiny of individual follicles. We discuss inconsistencies in the literature regarding the definitions of follicle recruitment and selection and propose to name the two major steps of follicle development as initial and cyclic recruitment, respectively. Because some of these disparities have arisen due to differences in the animal systems studied, we also compare the development of the ovarian follicles of both humans and rats. We also review the status of knowledge of several puzzling clinical issues that may provide important clues toward unlocking the mechanisms of follicle development. (Endocrine Reviews 21: 200 -214, 2000)

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Unilateral Ovariectomy Increases Loss of Primordial Follicles and is Associated with Increased Metestrous Concentration of Follicle-Stimulating Hormone in Old Rats1

Cited by 36 publications

References 24 publications

The impact of passive immunisation against BMPRIB and BMP4 on follicle development and ovulation in mice

The impact of passive immunisation against BMPRIB and BMP4 on follicle development and ovulation in mice

Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique

Initial and Cyclic Recruitment of Ovarian Follicles*

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