Unilateral Severe Chronic Periodontitis Associated With Ipsilateral Surgical Resection of Cranial Nerves V, VI, and VII

Abstract

This case report suggests that periodontal innervation may contribute to the regulation of local processes involved in periodontitis pathogenesis. It also suggests that periodontal therapy can be performed successfully at sites and in patients affected by paralysis.

Gingival Transcriptome Patterns During Induction and Resolution of Experimental Gingivitis in Humans

“…Additional neural genes modulated during induction include PMP22 and SNCA . Although, in humans, unilateral denervation (e.g., as a result of trauma) was associated with more severe disease ipsilaterally, the potential role of neural processes has been largely unexplored 25 . Increases in the neuropeptide substance P and neurokinin A were reported to be elevated in periodontitis, 26 but this may reflect macrophage activation.…”

“…Although, in humans, unilateral denervation (e.g., as a result of trauma) was associated with more severe disease ipsilaterally, the potential role of neural processes has been largely unexplored. 25 Increases in the neuropeptide substance P and neurokinin A were reported to be elevated in periodontitis, 26 but this may reflect macrophage activation. The clear signals for PKT2, as well as the dominance of the neural processing pathways shown in Figure 2, suggest that the role of neurogenic inflammation and its potential activity in maintaining homeostasis in response to biofilm overgrowth represent new areas for future investigation.…”

Denervation effectively aggravates rat experimental periodontitis

“…Numerous factors such as inflammatory mediators, growth factors, chemotactic factors and neuropeptides get involved in the deterioration of periodontal tissues . Nerve and neuropeptides should be potentially crucial factors in the process of periodontal inflammation in a direct and/or indirect way. Hence, we conducted the study first by denervation animal model to investigate the contribution of the inferior alveolar nerve (IAN) in experimental periodontitis and lay a theoretical foundation for future inflammation regulation and periodontal tissue regeneration.…”

Quantitative evaluation of oral function in acute and recovery phase of idiopathic facial palsy; a preliminary controlled study

“…Retained food in association with postoperative or post‐stroke facial palsy worsens oral hygiene and leads to dental caries and periodontal diseases . Therefore, peripheral facial palsy probably worsens patient quality of life in terms of aesthetics, mastication and hygiene.…”

“…5 Retained food in association with postoperative or poststroke facial palsy worsens oral hygiene and leads to dental caries and periodontal diseases. 6,7 Therefore, peripheral facial palsy probably worsens patient quality of life in terms of aesthetics, mastication and hygiene. Thus, we conducted a study to elucidate the role of the facial muscles by observing oral function during eating in patients with peripheral facial palsy.…”