Unique variations of the distribution coefficients of homologues in the perfluorodecalin-acetonitrile heterophase system

Totally organic biphasic solvent systems for extraction and descriptor determinations

“…This is important for the accurate determination of partition coefficients but may be less relevant, or even a disadvantage, in classical liquid–liquid extraction where volume reduction by evaporation is a common operation. The rather limited quantitative information for the mutual solubility of totally organic biphasic systems is summarized in Table . Mutual solubility is generally low in these systems and most are suitable for sample preparation where low mutual solubility is considered desirable to minimize carryover.…”

“…Fluorous solvents are a specialty group of solvents used for the isolation of fluorine‐containing compounds from reaction mixtures and sometimes more complex matrices . Applications involving nonfluorinated compounds are uncommon , except after derivatization to incorporate a perfluorocarbon chain into the compound to act as a tag to facilitate its isolation. There is a reasonable amount of information for partition coefficients for the perfluoro(methylcyclohexyl)/toluene and perfluorodecalin/ACN biphasic systems, but mainly for fluorine‐containing compounds.…”

“…Applications involving nonfluorinated compounds are uncommon , except after derivatization to incorporate a perfluorocarbon chain into the compound to act as a tag to facilitate its isolation. There is a reasonable amount of information for partition coefficients for the perfluoro(methylcyclohexyl)/toluene and perfluorodecalin/ACN biphasic systems, but mainly for fluorine‐containing compounds. The poor solvation of organic compounds and preference for highly fluorinated compounds exhibited by fluorous solvents has more to do with the relatively weak dispersion forces between highly fluorinated and hydrocarbon‐like compounds than with a strong affinity between highly fluorinated compounds .…”