2017
DOI: 10.1038/s41556-017-0011-1
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Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

Abstract: The resolution of joint molecules that link recombining sister chromatids is essential for chromosome segregation. Here, we determine the fate of unresolved recombination intermediates that arise in GEN1-/- knock-out cells depleted for MUS81, the two nucleases required for resolution. We find that intermediates persist until mitosis where they form a distinct class of anaphase bridges, which we term homologous recombination ultra-fine bridges, or HR-UFBs. The HR-UFBs are distinct from replication stress-associ… Show more

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Cited by 161 publications
(201 citation statements)
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“…Several observations support the notion that HR-UFBs are distinct from all types of previously described UFBs [22,23]. First, in contrast to FS-UFBs, HR-UFBs do not associate with FANCD2 foci, a marker of late replication intermediates.…”
Section: The Origin Of Hr-ufbssupporting
confidence: 78%
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“…Several observations support the notion that HR-UFBs are distinct from all types of previously described UFBs [22,23]. First, in contrast to FS-UFBs, HR-UFBs do not associate with FANCD2 foci, a marker of late replication intermediates.…”
Section: The Origin Of Hr-ufbssupporting
confidence: 78%
“…Recently, two laboratories confirmed this notion and identified a new class of UFBs that are generated by homologous recombination [22,23]. In this article, we summarize and discuss how HR-UFBs are generated, which proteins are recruited, and their roles in bridge processing.…”
Section: Introductionmentioning
confidence: 93%
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