The principal objective of the current study is to analyze the Brownian motion and thermophoretic impacts on micropolar nanofluid flow over a nonlinear inclined stretching sheet taking into account the Soret and Dufour effects. The compatible similarity transformations are applied to obtain the nonlinear ordinary differential equations from the partial differential equations. The numerical solution of the present study obtained via the Keller-Box technique. The physical quantities of interest are skin friction, Sherwood number, and heat exchange, along with several influences of material parameters on the momentum, temperature, and concentration are elucidated and clarified with diagrams. A decent settlement can be established in the current results with previously published work in the deficiency of incorporating effects. It is found that the growth of the inclination and nonlinear stretching factor decreases the velocity profile. Moreover, the growth of the Soret effect reduces the heat flux rate and wall shear stress.