Untersuchung zur Ermittlung des Anwendungsnutzens von Weleda Heuschnupfenspray unter besonderer Berücksichtigung der Wirkungsdynamik − Ergebnisse einer prospektiven Beobachtungsstudie

Rother, Claudia

doi:10.1016/j.kim.2008.07.024

Cited by 6 publications

(11 citation statements)

References 7 publications

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“…The positive results of this study are in line with clinical experiences [4], in vitro studies [7, 8], and cohort studies [5, 6]. …”

Section: Discussionsupporting

confidence: 86%

“…[4]. Positive effects, without side effects, were also observed in two cohort studies: a group of 13 patients suffering from grass pollen SAR treated with subcutaneous injections [5] and a group of 140 patients, who were treated with nasal spray [6]. Recently, the immunological pathways underlying the positive effects of Citrus/Cydonia comp.…”

Section: Introductionmentioning

confidence: 98%

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Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Baars

Jong

Nierop³

et al. 2011

ISRN Allergy

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Background. Clinical experiences in vitro and clinical studies have demonstrated the curative potency and safety of Citrus/Cydonia compositum in seasonal allergic rhinitis treatment. Objectives. To compare the efficacy and safety of two routes of administration (nasal spray versus subcutaneous injections). Methodology: Design. a national, randomised, comparative clinical trial with two parallel groups. Participants. 23 patients fulfilled the study requirements. Intervention. after a one- or two-week wash-out period, 23 patients were randomized, to a 6-week treatment period. Outcomes. immunological and symptom severity changes and safety. Immunologic outcome assessments were blinded to group assignment. 23 patients were randomized and from 22/23 patients (11 in each group) blood samples were analyzed before and after treatment. Conclusion. Both routes of administration demonstrate immunological and clinical effects, with larger inflammatory and innate immunological effects of the nasal spray route and larger allergen-specific clinical effects of the subcutaneous route, and are safe.

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“…The positive results of this study are in line with clinical experiences [4], in vitro studies [7, 8], and cohort studies [5, 6]. …”

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 98%

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Baars

Jong

Nierop³

et al. 2011

ISRN Allergy

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“…The combination of both plant extracts was chosen because synergistic effects were expected. An observational study with 140 patients suffering from seasonal allergic rhinitis reported a positive outcome without major adverse effects [6]. Moreover, studies on peripheral blood mononuclear cells taken from allergic and nonallergic donors showed antiallergic activity of a Citrus/Cydonia preparation [7].…”

mentioning

confidence: 99%

In VitroAntiallergic Effects of Aqueous Fermented Preparations fromCitrusandCydoniafruits

et al. 2011

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This study aimed to investigate the immunomodulatory and antiallergic properties of preparations from lemon, Citrus medica L. (citrus), and quince, Cydonia oblonga Mill. (Cydonia), which are used in pharmaceutical products to treat patients suffering from allergic disorders. Preparations were analyzed with respect to their impact on the degranulation capacity from basophilic cells as well as mediator release from activated human mast cells in vitro, including IL-8 and TNF- α secretion. The results show that the degranulation of basophilic cells was diminished only in the presence of Citrus, and this effect was compared to the synthetic drug azelastine. Furthermore, Citrus and Cydonia both inhibited the production of IL-8 and TNF- α from human mast cells, and at low concentrations additive effects were observed. As a positive inhibition control, dexamethasone was used. LC-MS analyses showed that the major phenolic components in extracts from Citrus and Cydonia are eriocitrin and neochlorogenic acid, respectively. Nevertheless, these compounds do not show biological effects at concentration levels detected in their corresponding extracts. In conclusion, the present data provide a rational base for the use of the single pharmaceutical preparations from Citrus and Cydonia in a differentiated treatment of allergic disorders in part by the regulation of soluble allergic mediators from basophilic cells and mast cells.

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“…Previous in vitro studies and clinical studies already repeatedly demonstrated positive treatment effects of Citrus/Cydonia on immunological and clinical SAR-related elements [2–6]. The primary hypothesis of the present study was that the combination product Citrus/Cydonia would demonstrate larger SAR-related immunological treatment effects in vitro than each of the single products.…”

Section: Discussionmentioning

confidence: 72%

A ComparativeIn VitroStudy of the Effects of Separate and Combined Products ofCitrus e fructibusandCydonia e fructibuson Immunological Parameters of Seasonal Allergic Rhinitis

Baars

Jong

Boers

et al. 2012

Mediators of Inflammation

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This paper examined the effects of the combined product, Citrus e fructibus/Cydonia e fructibus (Citrus/Cydonia; Citrus and Cydonia: each 0.01 g/mL), and separate products of Citrus (0.01 g/mL) and Cydonia (0.01 g/mL) on the immunological pathways involved in seasonal allergic rhinitis (SAR). Peripheral blood mononuclear cells (PBMCs) from five healthy and five grass pollen-allergic donors were isolated and analyzed in vitro after polyclonal and allergen-specific stimulation of T cells in the presence of the three extracts. The analyses demonstrated acceptable cell survival with no signs of toxicity. Citrus mainly had a selective effect on reducing allergen-specific chronic inflammatory (TNF-α; Citrus compared to Cydonia and Citrus/Cydonia: −87.4 (P < 0.001) and −68.0 (P < 0.05), resp.) and Th2 pathway activity (IL-5; Citrus compared to Cydonia: −217.8 (P < 0.01); while, both Cydonia and Citrus/Cydonia mainly affected the induction of the allergen-specific Th1 pathway (IFN-γ; Cydonia and Citrus/Cydonia compared to Citrus: 3.8 (P < 0.01) and 3.0 (P < 0.01), resp.). Citrus and Cydonia demonstrated different working mechanisms in the treatment of SAR and the combination product did not demonstrate larger effects than the separate preparations. Further effectiveness and efficacy studies comparing the effects of the products on SAR in vivo are indicated.

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Untersuchung zur Ermittlung des Anwendungsnutzens von Weleda Heuschnupfenspray unter besonderer Berücksichtigung der Wirkungsdynamik − Ergebnisse einer prospektiven Beobachtungsstudie

Cited by 6 publications

References 7 publications

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

In VitroAntiallergic Effects of Aqueous Fermented Preparations fromCitrusandCydoniafruits

A ComparativeIn VitroStudy of the Effects of Separate and Combined Products ofCitrus e fructibusandCydonia e fructibuson Immunological Parameters of Seasonal Allergic Rhinitis

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