Unusual adverse effect of dexmedetomidine and its management

Selvaraj, Sathishkumar; Panneerselvam, Sakthirajan

doi:10.4103/ija.ija_66_18

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…28–31 Though this polyuric response has not been demonstrated in human studies, a growing number of case reports has suggested a link between dexmedetomidine use and DI. 5–13,25,26 Case reports have implicated both continuous infusions for several hours as well as a single loading dose of 1 μg/kg. 12…”

Section: Discussionmentioning

confidence: 99%

“…[28][29][30][31] Though this polyuric response has not been demonstrated in human studies, a growing number of case reports has suggested a link between dexmedetomidine use and DI. [5][6][7][8][9][10][11][12][13]25,26 Case reports have implicated both continuous infusions for several hours as well as a single loading dose of 1 μg/kg. 12 Sevoflurane is a commonly used volatile anesthetic and was the second most frequently implicated cause of DI in 43.8% of exposures in our study.…”

Section: Discussionmentioning

confidence: 99%

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Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature

Decar¹,

Reynolds

Sharpe

et al. 2021

Anesthesia &Amp; Analgesia

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Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 29 cases of DI related to medications commonly used in anesthesia such as propofol, dexmedetomidine, sevoflurane, ketamine, and opioids. This review summarizes the case reports and frequency of DI with each medication and presents possible pathophysiology. Medication-induced DI should be included in the differential diagnosis when intraoperative polyuria is identified. Early identification, removal of the agent, and treatment of intraoperative DI are critical to minimize complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature

Decar¹,

Reynolds

Sharpe

et al. 2021

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

show abstract

“…Literature search revealed sporadic reports of spinal surgeries and mandibulectomy where dexmeditomidine was implicated for polyuria and electrolytic disbalance. [ 2 3 4 ] Dexmedetomidine produces diuresis by inhibiting or reducing the effects of vasopressin, inhibiting renin secretion or secreting atrial natriuretic peptide. [ 5 6 ] This diuretic effect leads to polyuria, serum hyperosmolality and urine hypoosmolality.…”

mentioning

confidence: 99%