Unusual diffuse [131I]MIBG accumulation in a kidney with renal artery stenosis

A Pitfall of Metaiodobenzylguanidine Scan: Paraganglioma in Close Proximity to Adrenocortical Adenoma

“…False positive findings of MIBG scan are suggested to be rare. Previously, there have been less than 20 reports of false positive cases (Shapiro et al, 1985b;Kao et al, 1996;Bahar et al, 1988;Bathmann et al, 1994;Krubsack et al, 1988;Sone et al, 1996;Rainis et al, 2000;Horne et al, 1991;Cortes-Blanco et al, 2000). We report the case of concurrent presentation of adrenocortical adenoma and paraganglioma, which due to MIBG finding was suspected to be intra-adrenal pheochromocytoma.…”

“…Moreover, the radiation dose is considerably smaller with 123 I-MIBG as compared to 131 I-MIBG (Kloos et al, 1998). Although false positive findings of MIBG scan have been considered rare, almost 20 false such cases have been reported, due to various reasons (Shapiro et al, 1985b;Kao et al, 1996;Bahar et al, 1988;Bathmann et al, 1994;Krubsack et al, 1988;Sone et al, 1996;Rainis et al, 2000;Horne et al, 1991;Cortes-Blanco et al, 2000;Jacobs et al, 1990;Hanson et al, 1991;Gallar et al, 1993;Fischer et al, 1984;Letizia et al, 1998;Ünal et al, 1995;Burt et al, 2002). Prolonged retention of isotope due to dilated renal pelvis or hydronephrosis was the reason in 4 cases Kao et al, 1996;Bahar et al, 1988;Bathmann et al, 1994) and abnormalities in the route excretion was also possibly the reason in the case of a renal failure (Gallar et al, 1993), a small ischemic kidney (Horne et al, 1991), a kidney with renal artery stenosis (Cortes-Blanco et al, 2000) and a focal pyelonephritis (Jacobs et al, 1990).…”

Unusual Renal Uptake of 131I-MIBG in a Young Hypertensive With Renal Artery Stenosis

“…131 I-MIBG scintigraphy has been conventionally used to detect neural crest cell-derived tumors. 1,2 Diffusely increased MIBG uptake in a kidney due to RAS [3][4][5][6] or external compression of renal artery by a tumor 7 has been described only in a few cases in the literature. A unique feature of this case is demonstration of hemodynamic significance of RAS by a positive losartan renal scintigraphy that has not been shown in other similar cases.…”

123I MIBG Appearance of Severe Renal Artery Stenosis

“…2 A rare false-positive cause of diffusely increased MIBG accumulation within the kidney is renal artery stenosis, described previously in a study performed with iodine-131 MIBG. 4,5 Other reported causes of diffusely increased MIBG activity within the renal parenchyma include renal dysfunction due to obstruction 6,7 and acute pyelonephritis. 8 …”