Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature

Gültekin, Sibel Elif; Şengüven, Burcu; Gönül, İpek Işık; Okur, Begüm; Buettner, Reinhard

doi:10.1016/j.joms.2016.06.004

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…Clinically, metastasis to the oral and maxillofacial region (MOMR) may resemble benign inflammatory and hyperplastic lesions such as pyogenic granuloma and epulis fissuratum (Nuyen & Tang, 2016; Shen et al., 2009; Vasilyeva, Peters, Philipone, & Yoon, 2018). Progressive swelling, pain, and paresthesia constituted the most usual symptoms involving the maxillary bones (Gultekin, Senguven, Isik Gonul, Okur, & Buettner, 2016; Hirshberg et al., 2014; Irani, 2016). Imaginological features are non‐specific and a lytic lesion with a radiolucent image with ill‐defined margins is frequently observed.…”

Section: Introductionmentioning

confidence: 99%

Metastasis to the oral and maxillofacial region: A systematic review

Kirschnick

Schuch²,

Cademartori

et al. 2020

Oral Diseases

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Objectives The purpose of this systematic review was to incorporate the information published on metastatic lesions in the in the oral and maxillofacial region into a comprehensive analysis of their demographic, clinical, and imaginological features and survival rate. Materials and methods An electronic search was undertaken in the subsequent databases: PubMed, Web of Science, Scopus, EMBASE, and LILACS. All papers included were case reports or case series. Absolute and relative frequencies were obtained by descriptive analysis. Overall survival was defined by the Kaplan–Meier method. Results This systematic review identified 217 studies from 33 countries, comprising 348 cases. Male individuals were more affected (n = 199/57.68%) in the 5th to 7th decades of life. The most usual primary site was the lung in men (n = 49/14.08%) and the breast in women (n = 40/11.49%). Jawbones were affected in 183 cases (53.19%), with the posterior mandible (n = 96/66.66%) representing the preferred site. In soft tissues, the gingiva (n = 80/23.25%) was more affected. Clinical presentation was a nodular mass with or without ulceration (n = 280/85.89%). Imaginological examinations revealed radiolucent/hypodense lesions (n = 115/59.28%). The mean survival time was eight months. Conclusion Despite the rare occurrence of metastatic lesions in the oral and maxillofacial region, the current systematic review offers substantial data that could assist clinicians and surgeons.

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Section: Introductionmentioning

confidence: 99%

Metastasis to the oral and maxillofacial region: A systematic review

Kirschnick

Schuch²,

Cademartori

et al. 2020

Oral Diseases

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“…Lung cancer, one of the most prevalent conditions in the world, is the most frequent cause of cancer-related death worldwide, and smoking is the predominant risk factor ( 11 - 13 ). Moreover, the lung is the most common source for metastasis to the oral soft tissues in men, and the attached gingiva is the most common affected site followed by the tongue ( 1 , 6 , 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…The age of our patient in Case 2 was 61 years, the initial detection time of the primary esophageal carcinoma and diagnosis of the oral metastasis was four months and the death after diagnosis of metastasis in the mouth was one month. The patient’s smoking history, along with advancing age would be major risk factors for the development of carcinoma ( 12 , 13 ). It is important to note that rapid swelling, pain and paresthesia can be cardinal symptoms of oral metastasis ( 2 , 4 ), as in our case where the patient also presented with hypoesthesia on the lower lip on the right.…”

Section: Discussionmentioning

confidence: 99%

Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma

et al. 2020

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Metastasis to the oral cavity are rare, representing only 1% of all oral malignancies, and originate from various sites such as the breast, prostate, lung and kidney. Clinically, they can simulate reactive and inflammatory lesions common in the oral cavity, and the clinical and microscopic diagnosis of these metastasis is a challenge. In this article, we report two new cases of esophageal and lung metastasis to oral tissues, highlighting their clinical characteristics and the process of diagnostic elucidation. We emphasize the importance for clinicians to consider the possibility of metastatic lesions in the oral cavity in patients previously diagnosed with malignant lesions in distant tissues and organs. Key words: Diagnosis, esophageal squamous cell carcinoma, adenocarcinoma of lung, oral cavity, metastasis.

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“…[ 9 ] Clinicians may misdiagnose the presence of a malignant lesion as a dental disease, such as periodontal disease, because most odontogenic infections cause pain and swelling in the orofacial region. [ 2 ] Establishing an accurate diagnosis as soon as possible is important because the interval between the occurrence of metastasis to the oral region and patient death is usually a few months. [ 1 ] Accurate medical history of the patient with atypical symptoms in the OMR must be obtained because metastatic lesion to the OMR may be the first clinical indication of an undiscovered distant primary tumor or CUP.…”

Section: Discussionmentioning

confidence: 99%

“…The lung is the most common primary site metastasizing to the jaw, and the most common histologic type is squamous cell carcinoma, followed by adenocarcinoma. [ 2 ] According to previous literature, the primary lesions could be detected by imaging examination at the same time when the mandibular metastases were revealed, and patients sometimes had medical histories associated with the metastases. [ 1 , 2 ] The authors present a case of mandibular metastasis as the first clinical indication of occult lung adenocarcinoma with multiple metastases.…”

Section: Introductionmentioning

confidence: 99%

Mandibular metastasis as the first clinical indication of occult lung adenocarcinoma with multiple metastases

et al. 2018

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Rationale:Although metastases to the oral and maxillofacial region (OMR) are rare, the lung is the most common primary site metastasizing to the OMR.Patient concerns:An 83-year-old woman presented with reports of trismus, occlusal discomfort, swelling, and spontaneous pain in the right buccal region. Despite the absence of abnormal chest imaging findings, immunohistochemical analysis of biopsy specimens of the mandible and the thyroid indicated that the patient had multiple metastases from a lung poorly differentiated adenocarcinoma.Diagnoses:Metastases to the OMR and the thyroid from an undiscovered lung adenocarcinoma.Interventions:Gefitinib was started as first-line chemotherapy, and zoledronic acid was administered for bone metastases.Outcomes:Follow-up imaging examinations showed ossification and deformation of the right mandibular ramus and the condylar process. Although 2 years have passed since the first visit to our hospital, lung lesions have not been confirmed by imaging examinations.Lessons:Clinicians should consider the possibility that symptoms in the OMR may be the first clinical sign of an undiscovered distant primary tumor, and the primary tumors may not be detected by imaging examinations even when metastases to the OMR are revealed.

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Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature

Cited by 8 publications

References 32 publications

Metastasis to the oral and maxillofacial region: A systematic review

Metastasis to the oral and maxillofacial region: A systematic review

Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma

Mandibular metastasis as the first clinical indication of occult lung adenocarcinoma with multiple metastases

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