Up-regulation of Ca2+ channels in vas deferens after chronic treatment of newborn rats with nifedipine

Verde, Luciana Ferreira; Lafayette, Simone S.L.; Caricati‐Neto, Afonso; Jurkiewicz, Neide Hyppolito; Jurkiewicz, Aron

doi:10.1016/s0014-2999(02)01584-4

Cited by 5 publications

(2 citation statements)

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“…As a matter of fact, we have shown that rat pups injected with the calcium channel blocker nifedipine presented an up-regulation of these channels in rat vas deferens (Verde et al 2002). In addition, in another experimental approach, a reversible decrease of responsiveness to serotonin and noradrenaline was detected for pups that were breast-fed with the milk of mothers injected daily with the serotonin neuronal uptake blocker fluoxetine (Pereira et al 2007).…”

Section: Agingmentioning

confidence: 90%

“…In the last decades of the previous century, the Ariens' so-called stimulus was already considered as a transducing or signaling pathway, comprising second messengers such as cyclic AMP (Sutherland 1972), Gproteins (Hill 2006, Milligan andKostenis 2006), and some ions as calcium (Jurkiewicz et al 1975, 1994b, Castillo et al 1992, Smaili et al 1998, Verde et al 2002, Lopes et al 2006, Lafayette et al 2008), sodium (Belevych et al 1999), or potassium (Harhun et al 2003. This picture was further improved thanks to the development of new methods, such as receptor binding with radioligands as for instance by Castillo et al (1992), and electrical identification of selective ion channels (Belevych et al 1999, Harhun et al 2003.…”

Section: The Receptor Systems In Smooth Musclementioning

confidence: 99%

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Functionomics: the analysis of a postgenomic concept on the basis of pregenomic pharmacological studies in smooth muscle

Jurkiewicz

Caricati‐Neto

Jurkiewicz

2009

An. Acad. Bras. Ciênc.

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The term functionomics (Amin 2003, Neumann et al. 2004 refers to a postgenomic integrated Systems Biology (Attur et al. 2002) using a multidimensional approach for cells, tissues and organs. It considers current or future involvement among genomics, proteomics or metabolomics, including the main factors that cause biological responses and modulation under different conditions. Our objective in the present review is to summarize the contemporary understanding of functionomics of smooth muscle pharmacology, based on the results obtained on the pregenomic era during several years in our laboratory. The present approach is based on the knowledge of the dynamics of the receptor system, which comprises a cascade of phenomena, leading from the drug administration to the final biological response. We will describe several conditions in which the final effect is modified, based on perturbations induced on drug absorption, distribution, metabolism, interaction with receptors and mobilization of second messengers, as well as by interactions with a second receptor system. We will also discuss the gaps that need to be fulfilled in order to obtain a clear and better understanding of the receptor system in smooth muscle, and to narrow the bridge between our knowledge of the function of biological systems, genomics, and other recently introduced areas.

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Section: Agingmentioning

confidence: 90%