Up-regulation of Chemokine Ligand 20 in Chronic Rhinosinusitis

Abstract

Objectives: To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa.

Distribution of Inflammatory Cells, Adhesion Molecules, Intermediate Filaments, and Chemokine Receptors in Subgroups of Nasal Polyp Patients

“…As CCL20, CD184 expression may be involved in chemokine microenvironment regulation of paranasal sinus mucosal epithelial cells, thereby influencing immature dendritic cell migration. 40 We observed a relatively stronger CD184 reactivity in patients with Samter syndrome and we conclude that in patients with Samter syndrome, inflammation was more severe.…”

Higher Levels of CCL20 Expression on Peripheral Blood Mononuclear Cells of Chinese Patients with Inflammatory Bowel Disease

“…Conceivably, the significantly reduced levels of CCL20 expression may also be used as a surrogate measure for monitoring the efficacy of drug treatment in Chinese IBD patients. CCL20 expression on skin and mucosal surfaces plays a critical role in chemoattraction of immature dendritic cells (DC) and effector/memory lymphocytes (Schutyser et al, 2003;Yamauchi et al, 2003;Lee et al, 2006Lee et al, , 2008Wu et al, 2009;Yoshida et al, 2009). Histological analysis of endoscopic colonic biopsies revealed higher levels of CCL20 expression in intestinal tissues from IBD patients (Puleston et al, 2005;Noble et al, 2006).…”

Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis

“…Additionally, CCL2, another potent DC chemoattractant, can be detected in high levels in bronchoalveolar lavage fluid following endobronchial allergen challenge 18. In addition to their role in immune cell recruitment, CCL2 and CCL20 have also been suggested to initiate Th2 skewing 19–22. In the upper airway CCL223 and CCL2021 have been detected in the nasal mucosa; however, the role of these factors in sinusitis remains unclear.…”