Up-regulation of hepatic heme oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon tetrachloride intraperitoneally

Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: Antioxidant and anti-inflammatory effects

“…In line with previous studies (Ibrahim et al, 2008;Wang et al, 2014;Yamaji et al, 2008), in this study there were significant increases in proinflammatory marker leptin, IL-6, LTB-4 and LTB-5 levels, beyond the IL-6/IL-10 ratio, after administration of CCl 4 , confirming that an inflammatory response was elicited at the site of injury.…”

Systemic inflammation as fuel for acute liver injury in COVID-19

“…IL-6 production may stem from immune cells [32] fibroblasts, endothelial cells [33] and hepatocytes [27 , 34] which orchestrates an hepatic acute phase response [32 , 35 , 36] . While IL-6 signaling impinges on hepatic regeneration [27] , clinical studies (that for example tested the effect of IL-6 administration in cancer patients) demonstrated a critical role of this pathway in hepatic injury and hepatotoxicity [37] , [38] , [39] . In line with a critical impact of systemic inflammation and specifically IL-6 on liver injury, we noted a direct correlation between acute phase proteins and IL-6 in the serum of COVID-19 patients with elevated AST.…”

Heme oxygenase‐1 directly binds STAT3 to control the generation of pathogenic Th17 cells during neutrophilic airway inflammation

“…With a variety of stimuli such as cytokines, ischemia‐reperfusion injury, inflammation, and radiation, HO‐1 expression can be upregulated and exert its enzymatic activities. Both IL‐6 and IL‐10 can promote HO‐1 expression through STAT3 signaling pathway . HO‐1 could also play a protective function through upregulation of IL‐10 and downregulation of IL‐6 expression .…”