uPA and PAI-1 in Rectal Cancer—Relationship to Radiotherapy and Clinical Outcome

Haglind, Eva; Langenskiöld, Marcus; Palmgren, Ingrid; Falk, Peter; Øresland, Tom; Ivarsson, Marie‐Louise

doi:10.1016/j.jss.2008.02.043

Cited by 29 publications

(30 citation statements)

References 32 publications

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“…The observed protein expression of uPA and PAI-1 was higher in tumour tissue compared with tumour-free mucosa which has previously been well documented [27,29,31] . Immunohistochemical studies have shown that uPA and PAI-1 expression is expressed mostly in the cytoplasm of tumour cells.…”

Section: Discussionsupporting

confidence: 65%

“…PAI-1 in tumour tissue has been related to increasing T status [27][28][29] , which is supported also by the present study. PAI-1 in tumour tissue has also been associated with poor survival in colorectal cancer [30,31] . In these studies, rectal cancer patients that received neoadjuvant radiotherapy were included, which might be one reason for the differing results, as no association with survival in relation to PAI-1 expression in tumour tissue was seen in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Differential Prognostic Impact of uPA and PAI-1 in Colon and Rectal Cancer

Langenskiöld

Holmdahl²,

Haglind³

et al. 2009

Tumor Biol

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Background and Objectives: Degradation of extracellular matrix is important for tumour growth and invasion, which in part is regulated by the plasminogen activation system. The aim of the study was to evaluate the protein expression of urokinase plasminogen activator (uPA) and plasminogen-activating inhibitor-1 (PAI-1) in plasma, tumour-free mucosa and tumour tissue regarding their prognostic value in colon and rectal cancer. Methods: Patients (n = 221) undergoing surgery for colorectal cancer were prospectively included. Samples were assayed by ELISA technique. Results: PAI-1 in tumour tissue (p = 0.006), plasma (<0.0001) and uPA in tumour-free mucosa (p = 0.006) were associated with survival in rectal cancer in univariate analysis. An uPA expression level below 1.1 ng/mg (log rank test, p < 0.0001) in tumour-free mucosa was associated with poor survival in rectal cancer. This was true also for patients without disseminated disease (M₀, p = 0.02). PAI-1 in plasma correlated with metastatic disease (p < 0.0001). uPA and PAI-1 were not associated with survival in either tumour tissue, mucosa or plasma in patients with colon cancer. Conclusions: uPA and PAI-1 have a differential prognostic impact in colon and rectal cancer. Preoperative mucosal uPA and plasma PAI-1 protein expression could possibly be used as prognostic factors in rectal cancer.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Differential Prognostic Impact of uPA and PAI-1 in Colon and Rectal Cancer

Langenskiöld

Holmdahl²,

Haglind³

et al. 2009

Tumor Biol

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“…For example, we have shown that irradiation induces both PAI-1 secretion and expression in squamous cell carcinomas of the head and neck (SCCHN) cell lines (14). Moreover, in a study of 90 rectal cancer patients, PAI-1 levels were found to be significantly higher in irradiated than nonirradiated tumor and mucosa tissue (15). We recently showed that pretreatment PAI-1 levels can predict for radiation resistance in xenograft tumors from 10 SCCHN cell lines (16).…”

Section: Introductionmentioning

confidence: 99%

Irradiation-Induced Regulation of Plasminogen Activator Inhibitor Type-1 and Vascular Endothelial Growth Factor in Six Human Squamous Cell Carcinoma Lines of the Head and Neck

Artman

Schilling

Gnann

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…[14] Degradation of extracellular matrix is important for tumour growth and invasion, which in part is regulated by the plasminogen activation system. [15,16,17] Therefore, an elevated plasma D-dimer level indicates activation of both coagulation and fibrinolysis. [8] The present study showed a significant difference between D-dimer levels in breast carcinoma patients pre-operatively and post-operatively as well as significantly higher levels in cases as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

Patel

Rashmi

Harish

2018

APALM

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Background: Breast cancer is the most common cause of death in women by neoplasia. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker, which is produced when factor XIIIa (a cross-linked fibrin) is degraded by plasmin. It is increased in various solid tumour patients including breast, lung, prostate, cervical and colorectal cancers.Methods: 30 patients of breast carcinoma who underwent radical mastectomy (cases) and 30 cases without carcinoma (controls) were included. The baseline parameters (D-dimer levels) were measured in both cases and controls. From each patient, whole blood was collected and Quantitative D-dimer levels were obtained by Diazyme's D-dimer Assay using the instrument, RANDOX Rx imola. Other parameters such as histopathological features, hormonal receptors (ER & PR) and HER2/neu status were studied in cases.Result: Mean plasma D-dimer levels were significantly higher in patients with breast carcinoma before surgery as compared to after surgery (p<0.001). Quantitative D-dimer levels highly correlated with lymph node status and histopathological grading (p=0.003, p=0.015 respectively). Conclusion:Our study showed that high plasma D-dimer levels can be used as a marker for lymph node involvement and higher histopathological grade. Due to the ease with which plasma D-dimer levels can be obtained and its cost effectiveness, quantitative D-dimer levels can be added to models for predicting axillary lymph node involvement.

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uPA and PAI-1 in Rectal Cancer—Relationship to Radiotherapy and Clinical Outcome

Cited by 29 publications

References 32 publications

Differential Prognostic Impact of uPA and PAI-1 in Colon and Rectal Cancer

Differential Prognostic Impact of uPA and PAI-1 in Colon and Rectal Cancer

Irradiation-Induced Regulation of Plasminogen Activator Inhibitor Type-1 and Vascular Endothelial Growth Factor in Six Human Squamous Cell Carcinoma Lines of the Head and Neck

D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

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