Er3+ Yb 3+ co-doped CaOWO 3 SiO 2 B 2 O 3 NaF glass ceramics containing CaWO 4 crystals were prepared by the melt-quench and crystallization method. The luminescence effect of the glass ceramic sample which was maintained for 70 min at 750°C exhibited the highest emission peak intensity in this work. As the crystallization time increased, the amount and the size of crystals increased and the crystal shape transformed from sphere to irregular polyhedron. Green and red up-conversion light appeared in the glass ceramics excited by 980 nm. Yb 3+ doped glass ceramics were investigated and the effect of excitation power on green and red light was analyzed. The up-conversion fluorescence intensity of the glass ceramics is the highest when the content of Er 2 O 3 is 0.5 wt % and the content of Yb 2 O 3 is 4.5 wt %.