Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society

Bilodeau, Elizabeth A.; Seethala, Raja R.

doi:10.1007/s12105-019-01013-5

Cited by 26 publications

(15 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The distinction between these two entities is clinically relevant, as COFs are generally expected to behave non-aggressively after treatment. Although controversy remains, several authors argue that these tumours are better classified as a variant of COF rather than a variant of CEOT classification, to avoid overtreatment 6 , 9 , 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the decreasing cost and increased throughput capacities of next generation sequencing (NGS) have led to rapid advances in the understanding of molecular pathogenesis of tumours, including odontogenic neoplasms 21 . Various signalling pathways regulate the process of odontogenesis 10 and some gene mutations seems to be clearly implicated in the pathogenesis of odontogenic tumours and odontogenic cystic neoplasms. Investigations focusing on RAS and BRAF mutations have been summarized in many studies 22 , 23 , although few studies focused specifically on rare lesions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Odontogenic fibroma amyloid-variant: a typical case and brief considerations about mimickers

et al. 2021

View full text Add to dashboard Cite

Summary The World Health Organization’s (WHO) updated classification of head and neck tumors (2017) defined odontogenic fibroma as a rare neoplasm. In this report, we describe an unusual, typical and rare variant of a central odontogenic fibroma with diffuse amyloid-like protein stromal deposition, and discuss the differential diagnosis with other entities. Radiographically, this lesion presented as a well-defined radiolucency of the mandible, partially cystic. Histologically, the lesion showed a unique confluence of odontogenic epithelial rests in a moderately cellular connective tissue. Immunohistochemical staining highlighted a mixture of benign epithelial and Langerhans cells within connective tissue with diffuse amyloid-like stromal deposition. The importance of recognizing this variant of odontogenic fibroma is due to its benign prognosis and clinical course.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Odontogenic fibroma amyloid-variant: a typical case and brief considerations about mimickers

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Yang et al (14) One of the largest and most recent series of ameloblastoma with prognostic data Darshani Gunawardhana et al (34) Another large series comparing maxillary with mandibular ameloblastomas Reichart et al (11) Molecular profile of ameloblastomas Sweeney et al (12) Molecular profile of ameloblastomas Slootweg (37) Description of tooth formation to better understand odontogenic lesions Bilodeau et al (38) A useful introduction in odontogenic tumors Wright et al (39) A useful introduction in odontogenic and maxillofacial bone tumors more radical approaches, such as en bloc resection with the possibility of 10-15 mm thickness of normal bone as margin, have shown lower percentages of recurrence (13).…”

Section: Maxillary Ameloblastomamentioning

confidence: 99%

Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor

Evangelou¹,

Zarachi²,

Dumollard³

et al. 2020

In Vivo

View full text Add to dashboard Cite

Diagnosis of odontogenic tumors can be challenging due to their rarity and diverse morphology, but when arising near the tooth, the diagnosis could be suspected. When their location is not typical, like inside the paranasal sinuses, the diagnosis is less easy. Maxillary ameloblastomas are exceedingly rare with only sparse information on their epidemiological, histological and genetic characteristics. The aim of this report is to thoroughly review the available literature in order to present the characteristics of this tumor. According to available data, maxillary ameloblastomas can occur in all ages but later than mandible ones, and everywhere within the maxillary region without necessarily having direct contact with the teeth. No sex preference has been shown. The most common histological patterns seen in this location are the follicular and plexiform ones. Maxillary ameloblastomas are locally aggressive neoplasms, thus therapy aims for excision including normal bone beyond the lesion. In contrast to mandible ameloblastomas, maxillary ones most commonly show mutations of the SMO gene. Furthermore, differential tumor diagnosis is thoroughly discussed in the present review. Odontogenic tumors are rare and can pose diagnostic difficulties for non-specialized pathologists. Nevertheless, when the location is typical, i.e. molar region and when the histology shows the characteristic features of odontogenic neoplasms, diagnosis could be straightforward. In locations outside the oral cavity or when rare histological variants are found, suspecting the correct diagnosis can be challenging. This is especially true for maxillary ameloblastomas, which are rare, possibly leading to low awareness of this neoplasm at this location and often show non-classical morphology, thus, rendering its diagnosis more complicated. Thus, the aim of this review is to define and thoroughly describe maxillary ameloblastomas based on the available literature after a short introduction in the entity of ameloblastoma.

show abstract

“…1 Regarding the histopathological variations of these OT, some have calcified matrices similar to dental enamel, as is the case of odontomas, and others have calcified matrices with structures that are more difficult to characterize, such as the calcifications observed in the calcifying epithelial odontogenic tumor (CEOT), the adenomatoid odontogenic tumor (AOT) and calcifying odontogenic cyst (COC). 2 In the enamel matrix, the most abundant protein is amelogenin that participates in the mineralization of enamel and in cell differentiation. 3 , 4 , 5 , 6 This protein has been identified in some OCs and OTs.…”

Section: Introductionmentioning

confidence: 99%

Amelogenin in calcified matrices of odontogenic cysts and odontogenic tumors: An immunohistochemical study

Urzúa

Ahumada-Ossandón

Casa-Weisser

et al. 2021

Journal of Dental Sciences

View full text Add to dashboard Cite

Background/purpose There are few studies comparing the expression of enamel proteins, such as amelogenin, and cytokeratins in cyst and odontogenic tumors like in ameloblastoma and odontogenic keratocyst, indicating that amelogenin could be a potential biomarker for the aggressiveness in the odontogenic tumors. The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. Materials and methods Three COC, eight CxO, three CdO, twelve AOT, two CEOT and three dental germs were submitted to an immunohistochemistry panel of antibodies composed of amelogenin, CKAE1/AE3 and CK14. Results CKAE1/AE3 and CK14 was present in all odontogenic epithelia. The amelogenin protein was detected in prismatic and amorphous calcified matrices of epithelial origin belonging to CxO, CdO, AOT, COC and the tooth germs used as controls. On the other hand, the CEOT was the only tumor or cyst studied that did not present immunostaining for amelogenin in calcified matrices. Conclusion Amelogenin was detected in pathologies with a low or absent recurrence rate and excellent prognosis. CEOT was the lesion of greater clinical aggressiveness which did not express amelogenin. The presence of amelogenin in calcified matrices of odontogenic arise could be an indicator of low aggressiveness.

show abstract

Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society

Cited by 26 publications

References 56 publications

Odontogenic fibroma amyloid-variant: a typical case and brief considerations about mimickers

Odontogenic fibroma amyloid-variant: a typical case and brief considerations about mimickers

Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor

Amelogenin in calcified matrices of odontogenic cysts and odontogenic tumors: An immunohistochemical study

Contact Info

Product

Resources

About