Update on risk factors and biomarkers of sudden unexplained cardiac death

Plasma extracellular vesicles microRNA-208b-3p and microRNA-143-3p as novel biomarkers for sudden cardiac death prediction in acute coronary syndrome

“…To date, identification of the cause of death in SCD cases also remains one of the most challenging subjects in forensic practice due to the lack of biomarkers. 4 Previous studies have shown that it is feasible to isolate EVs from post-mortem body fluids, and EVs RNAs are well-preserved, which could be used for forensic diagnosis. 52 It has been considered that miRNAs in EVs play an important role in cardiovascular diseases and may be able to provide objective evidence of SCD identification in forensic diagnosis.…”

“…3 The incidence of SCD is 41.84/100 000 persons per year in China. 4 Eighty percent of SCD cases are caused by coronary heart disease (CHD) and its complications, while the rest are caused by cardiomyopathy, heart valve disease, congenital heart disease, pulmonary embolism, etc. 5 Acute coronary syndrome (ACS) is the most serious subset of CHD and is life-threatening, affecting over a million people per year.…”

“…9 To date, identification of the cause of death in SCD cases also remains one of the most challenging subjects in forensic practice due to the lack of biomarkers. 4 Hence, there is an urgent need for exploring novel functional biomarkers for the prediction of SCD in patients with ACS and for forensic identification of SCD.…”

Characterization of global research trends and prospects on sudden coronary death: A literature visualization analysis

“…Along with the rapid development of computer technology, various artificial intelligence algorithms provide new means for massive data mining and analysis. ML may become a valuable tool for SCD risk prediction due to its capacity to find patterns that are difficult for humans to identify [ [85] , [86] , [87] ]. Radiological technology based on coronary artery calcification can also be a clue for the diagnosis of sudden coronary death [ 88 , 89 ].…”