Update on the Pattern Electroretinogram in Glaucoma

Bach, Michael; Hoffmann, Michael B.

doi:10.1097/opx.0b013e318177ebf3

Cited by 136 publications

(137 citation statements)

References 77 publications

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“…Therefore, the response asymmetries to square wave and sawtooth stimuli are possibly an indicator of inner retinal integrity similar to the PERG (Bach & Hoffmann, 2008;Bach et al, 2006;North, Jones, Drasdo, Wild & Morgan, 2010). In fact, Simpson & Viswanathan (2007) and Viswanathan et al (2000) used the response asymmetries to square wave stimuli to simulate the PERG.…”

Section: Introductionmentioning

confidence: 99%

Human photopic ON- and OFF-ERG responses elicited by square wave and sawtooth stimuli.

Pangeni

Kremers

2013

Psychology & Neuroscience

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In this study, the on-and off-responses elicited by luminance square wave and sawtooth stimuli at different temporal frequencies and contrasts are described quantitatively. Adding on-and off-responses reveals response asymmetries. Full-field stimuli were produced using a Ganzfeld bowl with arrays of light-emitting diodes (LEDs) as light sources. ERG responses were recorded from six normal subjects. The amplitudes and implicit times of components of the on-and off-responses and the additions were analyzed. The amplitudes of the on-, off-and addition components elicited by square wave stimuli did not depend on temporal frequency with the exception of the late negative components, which decreased with increasing temporal frequency up to 4 Hz. The amplitudes of all components elicited by sawtooth stimuli, except the P-on, decreased with increasing temporal frequency. The amplitude of all components elicited by square wave and sawtooth stimuli were positively correlated with stimulus contrast. The implicit times of the on-components to square wave stimuli and all response components to sawtooth stimuli decreased with increasing temporal frequency. Contrast had an effect on the implicit times of the N-on, P-on, P-off and P-add components elicited by square wave stimuli and the N-on, P-on, P-add and LN-on components elicited by sawtooth stimuli. The asymmetries between on-and off-responses can possibly be used to reveal inner retinal contributions and may therefore be interesting in detecting glaucomatous changes.

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Section: Introductionmentioning

confidence: 99%

Human photopic ON- and OFF-ERG responses elicited by square wave and sawtooth stimuli.

Pangeni

Kremers

2013

Psychology & Neuroscience

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“…There is now substantial evidence to suggest that this response originates principally from the spiking activity of inner retinal neurones, predominantly the retinal ganglion cells [2][3][4][5][6][7][8][9][10][11][12]1,13,14]. Previously, the electrophysiological assessment of inner retinal function had been largely dependent on the pattern electroretinogram (PERG) [15][16][17][18][19], a response which requires considerable averaging and is susceptible to reduction by refractive blur and media opacities [20], so the possibility of assessing ganglion cell function with the flash ERG is an attractive one.…”

Section: Introductionmentioning

confidence: 99%

The relationship between stimulus intensity and response amplitude for the photopic negative response of the flash electroretinogram

2011

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“…PERG presents a reversing black and white gradient, or checkerboard stimulus, to the central retina and provides a direct measure of RGC function [71 •• , 72, 73]. Preliminary data suggest that PERG abnormalities are measureable in early glaucoma and show moderate correlation with SAP values and with structural optic nerve assessments [74][75][76]. In addition, recent studies indicate that reversal of PERG abnormalities occurs following medical and surgical intervention for glaucoma.…”

Section: High-pass Resolution Perimetrymentioning

confidence: 99%

Functional Testing in Glaucoma Diagnosis

Sethi

Fay

Bollinger

2013

Curr Ophthalmol Rep

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The glaucomas are a group of diseases characterized by progressive optic neuropathy, often leading to partial or complete vision loss. Early recognition and careful monitoring for disease advancement are critical for prevention of vision loss. Frequently, asymptomatic defects in the patient's field of vision are key elements to diagnosis. Thus, it is important that the ophthalmologist stay informed regarding tools available for visual field assessment. This review will discuss the current functional testing modalities for glaucoma evaluation.

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Update on the Pattern Electroretinogram in Glaucoma

Cited by 136 publications

References 77 publications

Human photopic ON- and OFF-ERG responses elicited by square wave and sawtooth stimuli.

Human photopic ON- and OFF-ERG responses elicited by square wave and sawtooth stimuli.

The relationship between stimulus intensity and response amplitude for the photopic negative response of the flash electroretinogram

Functional Testing in Glaucoma Diagnosis

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